Publications

2017

33. Zieger K, Weiner J, Kunath A, Gericke M, Krause K, Kern M, Stumvoll M, Klöting N, Blüher M, Heiker JT: Ablation of kallikrein 7 (KLK7) in adipose tissue ameliorates metabolic consequences of high-fat diet induced obesity by counteracting adipose tissue inflammation in vivo. Cellular and Molecular Life Sciences, accepted manuscript
32. Zieger K, Weiner J, Krause K, Schwarz M, Kohn M, Stumvoll M, Blüher M, Heiker JT: Vaspin suppresses cytokine-induced inflammation in 3T3-L1 adipocytes via inhibition of NFκB pathway. Molecular and Cellular Endocrinology, doi.org/10.1016/j.mce.2017.07.022Abstract
31. Oertwig K, Ulbricht D, Hanke S, Pippel J, Bellmann-Sickert K, Sträter N, Heiker JT (2017) Glycosylation of human vaspin (SERPINA12) and its impact on serpin activity, heparin binding and thermal stability. BBA - Proteins and Proteomics, 1865 (9):1188–1194Abstract
30. Bürger F, Müller S, Ney N, Weiner J, Heiker JT, Kallendrusch S, Kovacs P, Schleinitz D, Thiery J, Stadler SC, Burkhardt R (2017) Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells. BBA - Molecular Basis of Disease, 1863 (7):1709-1717.Abstract

29. Weiner J, Rohde K, Krause K, Zieger K, Klöting N, Kralisch S, Kovacs P, Stumvoll M, Blüher M, Böttcher Y, Heiker JT (2017) Brown adipose tissue (BAT) specific vaspin expression is increased after obesogenic diets and cold exposure and linked to acute changes in DNA-methylation. Molecular Metabolism, 6 (6):482-493.

Abstract
28. Weiner J, Hankir MK, Heiker JT, Fenske WK, Krause K (2017) Thyroid Hormones and Browning of Adipose Tissue. Molecular and Cellular Endocrinology, dx.doi.org/10.1016/j.mce.2017.01.011Abstract
27. Hankir MK, Kranz M, Keipert S, Weiner J, Andreasen SG, Kern M, Patt M, Klöting N, Heiker JT, Brust P, Hesse S, Jastroch M, Fenske WK (2017) Dissociation between brown adipose tissue 18F-FDG uptake and thermogenesis in uncoupling protein 1 deficient mice. Journal of Nuclear Medicine, 58: 1100–1103Abstract
26. Ulbricht D, Oertwig K, Arnsburg K, Saalbach A, Pippel J, Sträter N, Heiker JT (2017) Basic Residues in β-Sheet A Contribute to Heparin Binding and Activation of Human Vaspin (Serpin A12). Journal of Biological Chemistry, 292: 994-1004. Abstract

2016

25. Weiner J, Kranz M, Klöting N, Kunath A, Steinhoff K, Rijntjes E, Köhrle J, Zeisig V, Hankir M, Gebhardt C, Deuther-Conrad W, Heiker JT, Fasshauer M, Stumvoll M, Blüher M, Sabri O, Hesse S, Brust P, Tönjes A, Krause K (2016) Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice. Scientific Reports, 6: 38124 Abstract
24. Hankir MK, Kranz M, Gnad T, Weiner J, Wagner S, Deuther-Conrad W, Bronisch F, Steinhoff K, Luthardt J, Klöting N, Hesse S, Seibyl JP, Sabri O, Heiker JT, Blüher M, Pfeifer A, Brust P, Fenske WK (2016) A novel thermoregulatory role for PDE10A in mouse and human adipocytes. EMBO Molecular Medicine, 8 (7): 796-812Abstract
23. Pippel J, Küttner EB, Ulbricht D, Daberger J, Schultz S, Heiker JT°, Sträter N° (2016) Crystal structure of cleaved vaspin (serpinA12). Biological Chemistry, 397 (2): 111–123Abstract
22. Saalbach A, Tremel T, Herbert D, Schwede K, Wandel E, Schirmer C, Anderegg U, Beck-Sickinger AG, Heiker JT, Schultz S, Magin T, Simon JC (2016) Anti-inflammatory action of keratinocyte-derived vaspin: relevance for the pathogenesis of psoriasis. American Journal of Pathology, 186 (3): 639-651Abstract

2015

21. Ulbricht D, Pippel J, Schultz S, Meier R, Sträter N, Heiker JT (2015) A Unique Serpin P1 Glutamate and a Conserved β-Sheet C Arginine are Key Residues for Activity, Protease Recognition and Stability of SerpinA12 (Vaspin). Biochemical Journal, 470 (3): 357-367Abstract
20. Mardinoglu A, Heiker JT, Gärtner D, Bjornson E, Schön MR, Flehmig G, Klöting N, Fasshauer M, Stumvoll M, Nielsen J, Blüher M (2015) Extensive weight loss reveals distinct gene expression changes in human subcutaneous and visceral adipose tissue. Scientific Reports, 5: 14841Abstract
19. Krause K, Weiner J, Hönes S, Klöting N, Rijntjes E, Heiker JT, Gebhardt C, Köhrle J, Führer D, Steinhoff K, Hesse S, Moeller LC, Tönjes A (2015) The Effects of Thyroid Hormones on Gene Expression of Acyl-Coenzyme A Thioesterases in Adipose Tissue and Liver of Mice. European Thyroid Journal, 4 (Suppl. 1): 59-66Abstract

2014

18. Heiker JT (2014) Vaspin (SerpinA12) in Obesity, Insulin Resistance and Inflammation. Journal of Peptide Science, 20 (5): 299-306Abstract
17. Heiker JT*, Kunath A*, Kosacka J, Flehmig G, Knigge A, Kern M, Stumvoll M, Kovacs P, Blüher M, Klöting N (2014) Identification of Genetic Loci Associated with Different Responses to High Fat Diet Induced Obesity (DIO) in C57BL/6N and C57BL/6J Substrains. Physiological Genomics, 46: 377-384Abstract
16. Kern M, Kosacka J, Hesselbarth N, Brückner J, Heiker JT, Flehmig G, Klöting I, Kovacs P, Matz-Soja M, Gebhardt R, Krohn K, Sales S, Abshagen K, Shevchenko A, Stumvoll M, Blüher M, Klöting N (2014) Liver-restricted Repin1 Deficiency Improves Whole Body Insulin Sensitivity, Alters Lipid Metabolism and Causes Secondary Changes in Adipose Tissue in Mice. Diabetes, 63 (10):3295-3309. Abstract

2013

15. Breitfeld J, Heiker JT, Böttcher Y, Schleinitz D, Tönjes A, Weidle K, Krause K, Küttner EB, Scholz M, Kiess W, Sträter N, Beck-Sickinger AG, Stumvoll M, Körner A, Blüher M, Kovacs P (2013) Analysis of a Rare Functional Truncating Mutation rs61757459 in Vaspin (SERPINA12) on Circulating Vaspin Levels. Journal of Molecular Medicine, 91 (11): 1285-1292Abstract
14. Heiker JT*, Klöting N*, Kovacs P, Küttner EB, Sträter N, Schultz S, Kern M, Stumvoll M, Blüher M, Beck-Sickinger AG (2013) Vaspin Inhibits Kallikrein 7 by Serpin Mechanism. Cellular and Molecular Life Sciences, 70 (14): 2569-2583Abstract
13. Schultz S, Saalbach A, Heiker JT, Meier R, Zellmann T, Simon JC, Beck-Sickinger AG (2013) Proteolytic Activation of Prochemerin by Kallikrein 7 Breaks an Ionic Linkage and Results in C-terminal Rearrangement. Biochemical Journal, 452 (2): 271-280Abstract
12. Kosacka J, Koch K, Gericke M, Nowicki M, Heiker JT, Klöting I, Stumvoll M, Blüher M, Klöting N (2013) The Polygenetically Inherited Metabolic Syndrome of Male WOKW Rats is Associated with Enhanced Autophagy in Adipose Tissue. Diabetology & Metabolic Syndrome, 5: 23Abstract
11. Heiker JT, Kern M, Kosacka J, Flehmig G, Stumvoll M, Shang E, Lohmann T, Dreßler M, Kovacs P, Blüher M, Klöting N (2013) Nicotinamide Nucleotide Transhydrogenase (NNT) mRNA Expression is Related to Human Obesity. Obesity, 21: 529–534Abstract
10. Heiker JT, Klöting N (2013) Replication initiator 1 in Adipose Tissue Function and Human Obesity. Vitamins and Hormones, 91: 97–105Abstract
9 Adams V, Heiker JT, Höllriegel R, Beck EB, Woitek FJ, Erbs S, Blüher M, Stumvoll M, Beck-Sickinger AG, Schuler G, Linke A (2013) Adiponectin Promotes the Migration of Circulating Angiogenic Cells Through p38-mediated Induction of the CXCR4 Receptor. International Journal of Cardiology, 167(5):2039-2046Abstract

2012

8. Kern M, Knigge A, Heiker JT, Kosacka J, Stumvoll M, Kovacs P, Blüher M, Klöting N (2012) C57BL/6JRj Mice are Protected against Diet Induced Obesity (DIO). Biochemical Biophysical Research Communications, 417: 717-720Abstract

2011

7. Klöting N, Kovacs P, Kern M, Heiker JT, Fasshauer M, Schön MR, Stumvoll M, Beck-Sickinger AG, Blüher M (2011) Central Vaspin Administration Acutely Reduces Food Intake and has Sustained Blood Glucose-lowering Effects. Diabetologia, 54 (7): 1819-23Abstract
6. Scholz M, Steinhagen M, Heiker JT, Beck-Sickinger AG, Hey-Hawkins E (2011) Asborin Inhibits Aldo/Keto Reductase 1A1. ChemMedChem, 6: 89-93Abstract

2010

5. Heiker JT, Klöting N, Blüher M, Beck-Sickinger AG (2010) Access to Gram Scale Amounts of Functional Globular Adiponectin from E. coli Inclusion Bodies by Alkaline-shock Solubilisation. Biochemical Biophysical Research Communications, 398 (1): 32-37Abstract
4. Heiker JT*, Kosel D*, Beck-Sickinger AG (2010) Molecular Mechanisms of Signal Transduction via Adiponectin and Adiponectin Receptors. Biological Chemistry, 391 (9): 1005-1018Abstract
3. Kosel D*, Heiker JT*, Juhl C, Wottawah CM, Blüher M, Mörl K, Beck-Sickinger AG (2010) Dimerization of Adiponectin Receptor 1 is Inhibited by Adiponectin. Journal of Cell Science, 123 (8): 1320-1328Abstract

2009

2. Heiker JT, Wottawah CM, Juhl C, Kosel D, Mörl K, Beck-Sickinger AG (2009) Protein Kinase CK2 Interacts with Adiponectin Receptor 1 and Participates in Adiponectin Signaling. Cellular Signalling, 21 (6): 936-942Abstract

2006

1. Deckert CM, Heiker JT, Beck-Sickinger AG (2006) Localization of Novel Adiponectin Receptor Constructs. Journal of Receptors and Signal Transduction, 26: 647-657Abstract

Patents

Heiker JT, Beck-Sickinger AG: Method of Producing Soluble Recombinant Protein.  WO002011131491A1 Abstract

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letzte Änderung: 13.09.2017

Kontakt

Dr. Dr. John T. Heiker
Institute of Biochemistry
University of Leipzig
Brüderstraße 34
D-04103 Leipzig

Telefon: +49 341 97-36990
E-Mail