All Publications

  • All Publications

Publications (all)

  1. M. Ansorge, J. Sapudom, M. Chkolnikov, M. Wilde, U. Anderegg, S. Moller, M. Schnabelrauch, and T. Pompe. Mimicking Paracrine TGFbeta1 Signals during Myofibroblast Differentiation in 3D Collagen Networks. Sci Rep 7:5664 (2017). Link
  2. J. Sapudom, X. Wu, M. Chkolnikov, M. Ansorge, U. Anderegg, and T. Pompe. Fibroblast fate regulation by time dependent TGF-beta1 and IL-10 stimulation in biomimetic 3D matrices. Biomater Sci 5:1858-67 (2017). Link
  3. M. Friedemann, L. Kalbitzer, S. Franz, S. Moeller, M. Schnabelrauch, J. C. Simon, T. Pompe and K. Franke. Instructing Human Macrophage Polarization by Stiffness and Glycosaminoglycan Functionalization in 3D Collagen Networks. Adv Healthc Mater  (2017). Link
  4. J. Sapudom, F. Ullm, S. Martin, L. Kalbitzer, J. Naab, S. Moller, M. Schnabelrauch, U. Anderegg, S. Schmidt, and T. Pompe. Molecular weight specific impact of soluble and immobilized hyaluronan on CD44 expressing melanoma cells in 3D collagen matrices. Acta Biomater 50:259-70 (2017). Link
  5. E. Muller, W. Wang, W. Qiao, M. Bornhauser, P. W. Zandstra, C. Werner, and T. Pompe. Distinguishing autocrine and paracrine signals in hematopoietic stem cell culture using a biofunctional microcavity platform. Sci Rep 6:31951 (2016). Link
  6. S. Martin, H. Wang, T. Rathke, U. Anderegg, S. Möller, M. Schnabelrauch, T. Pompe, and S. Schmidt. Polymer hydrogel particles as biocompatible AFM probes to study CD44/hyaluronic acid interactions on cells. Polymer 102:342-9 (2016). Link
  7. J. Sapudom, S. Rubner, S. Martin, and T. Pompe. Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces. Adv Healthc Mater 5:1861-7 (2016). Link
  8. M. Ansorge, N. Rastig, R. Steinborn, T. Konig, L. Baumann, S. Moller, M. Schnabelrauch, M. Cross, C. Werner, A. G. Beck-Sickinger, and T. Pompe. Short-range cytokine gradients to mimic paracrine cell interactions in vitro. J Control Release 224:59-68 (2016). Link
  9. C. Müller, and T. Pompe. Distinct impacts of substrate elasticity and ligand affinity on traction force evolution. Soft Matter 12:272-80 (2016). Link
  10. L. Kalbitzer, F. Franke, S. Möller, M. Schnabelrauch, and T. Pompe. Glycosaminoglycan functionalization of mechanically and topologically defined collagen I matrices. J Materials Chemistry B 3:8902-10 (2015). Link
  11. J. Sapudom, S. Rubner, S. Martin, S. Thoenes, U. Anderegg, and T. Pompe. The interplay of fibronectin functionalization and TGF-beta1 presence on fibroblast proliferation, differentiation and migration in 3D matrices. Biomater Sci 3:1291-301 (2015). Link
  12. E. Müller, T. Grinenko, T. Pompe, C. Waskow, and C. Werner. Space constraints govern fate of hematopoietic stem and progenitor cells in vitro. Biomaterials 53:709-15 (2015). Link
  13. J. Sapudom, S. Rubner, S. Martin, T. Kurth, S. Riedel, C. T. Mierke, and T. Pompe. The phenotype of cancer cell invasion controlled by fibril diameter and pore size of 3D collagen networks. Biomaterials 52:367-75 (2015). Link
  14. S. Martin, H. Wang, L. Hartmann, T. Pompe, and S. Schmidt. Quantification of protein-materials interaction by soft colloidal probe spectroscopy. Physical chemistry chemical physics : PCCP 17:3014-18 (2015). Link
  15. E. Bach, T. Zerjatke, M. Herklotz, N. Scherf, D. Niederwieser, I. Roeder, T. Pompe, M. Cross, and I. Glauche. Elucidating functional heterogeneity in hematopoietic progenitor cells: A combined experimental and modeling approach. Exp Hematol 42:826-37 (2014). Link
  16. D. Pussak, D. Ponader, S. Mosca, T. Pompe, L. Hartmann, and S. Schmidt. Specific Adhesion of Carbohydrate Hydrogel Particles in Competition with Multivalent Inhibitors Evaluated by AFM. Langmuir 30:6142-50 (2014). Link
  17. K. Franke, J. Sapudom, L. Kalbitzer, U. Anderegg, and T. Pompe. Topologically defined composites of collagen types I and V as in vitro cell culture scaffolds. Acta Biomater 10:2693-702 (2014). Link
  18. A. Muller, J. Meyer, T. Paumer, and T. Pompe. Cytoskeletal transition in patterned cells correlates with interfacial energy model. Soft Matter 10:2444-52 (2014). Link
  19. C. Müller, A. Müller, and T. Pompe. Dissipative Interactions in Cell-Matrix Adhesion. Soft Matter 9:6207-16 (2013). Link
  20. T. Pompe, M. Prewitz, and C. Werner. Polymere Biomaterialien als zelluläre Mikromilieus. Biospektrum 20:383-84 (2012). 
  21. M. Prewitz, F. P. Seib, T. Pompe, and C. Werner. Polymeric Biomaterials for Stem Cell Bioengineering. Macromol Rapid Commun 33:1420-31 (2012). Link
  22. D. Stamov, and T. Pompe. Structure and function of ECM-based composite collagen I scaffolds. Soft Matter 8:10200-12 (2012). Link
  23. H. Perez-Hernandez, T. Paumer, T. Pompe, C. Werner, and A. F. Lasagni. Contactless laser-assisted patterning of surfaces for bio-adhesive microarrays. Biointerphases 7:35-43 (2012). Link
  24. N. Zhang, T. Pompe, I. Amin, R. Luxenhofer, C. Werner, and R. Jordan. Tailored Poly(2-oxazoline) Polymer Brushes to Control Protein Adsorption and Cell Adhesion. Macromol Biosci 12:926-36 (2012). Link
  25. C. Müller, D. Stamov, C. Werner, and T. Pompe. Nanoscale Characterization of Cell Receptors and Binding Sites on Cell-Derived Extracellular Matrices. Ultramicroscopy 118:44-52 (2012). Link
  26. J. Teichmann, A. Morgenstern, J. Seebach, H. J. Schnittler, C. Werner, and T. Pompe. The control of endothelial cell adhesion and migration by shear stress and matrix-substrate anchorage. Biomaterials 33:1959-69 (2012). Link
  27. N. Scherf, K. Franke, I. Glauche, I. Kurth, M. Bornhäuser, C. Werner, T. Pompe, and I. Roeder. On the symmetry of siblings: automated single-cell tracking to quantify the behavior of hematopoietic stem cells in a biomimetic setup. Exp Hematol 40:119-30 (2012). Link
  28. I. Roeder, M. Loeffler, and I. Glauche. Towards a quantitative understanding of stem cell-niche interaction: experiments, models, and technologies. Blood Cells Mol Dis 46:308-17 (2011). Link
  29. D. R. Stamov, T. A. Khoa Nguyen, H. M. Evans, T. Pfohl, C. Werner, and T. Pompe. The impact of heparin intercalation at specific binding sites in telopeptide-free collagen type I fibrils. Biomaterials 32:7444-53 (2011). Link
  30. I. Kurth, K. Franke, T. Pompe, M. Bornhauser, and C. Werner. Extracellular matrix functionalized microcavities to control hematopoietic stem and progenitor cell fate. Macromol Biosci 11:739-47 (2011). Link
  31. M. Kaufmann, Y. Jia, C. Werner, and T. Pompe. Weakly coupled lipid bilayer membranes on multistimuli-responsive poly(N-isopropylacrylamide) copolymer cushions. Langmuir 27:513-6 (2011). Link
  32. T. Pompe, M. Kaufmann, M. Kasimir, S. Johne, S. Glorius, L. Renner, M. Bobeth, W. Pompe, and C. Werner. Friction controled traction forces in cell adhesion. Biophys J 101:1863-70 (2011). Link
  33. L. Renner, T. Pompe, R. Lemaitre, D. Drechsel, and C. Werner. Controlled enhancement of transmembrane enzyme activity in polymer cushioned supported bilayer membranes. Soft Matter 6:5382-89 (2010). Link
  34. T. Pompe, K. Salchert, K. Alberti, P. Zandstra, and C. Werner. Immobilization of growth factors on solid supports for the modulation of stem cell fate. Nat Protoc 5:1042-50 (2010). Link
  35. K. Lehmann, M. Herklotz, M. Espig, T. Paumer, M. Nitschke, C. Werner, and T. Pompe. A new approach to biofunctionalisation and micropatterning of multi-well plates. Biomaterials 31:8802-9 (2010). Link
  36. M. Kaufmann, Y. F. Jia, L. Renner, S. Gupta, D. Kuckling, C. Werner, and T. Pompe. Tuneable swelling of thermo- and pH-responsive copolymer films. Soft Matter 6:937-44 (2010). Link
  37. R. Grombe, M. F. Gouzy, U. Freudenberg, T. Pompe, S. Zschoche, F. Simon, K. J. Eichhorn, A. Janke, B. Voit, and C. Werner. Sulfated cellulose thin films with antithrombin affinity. Express Polym Lett 3:733-42 (2009). Link
  38. T. Pompe, S. Glorius, T. Bischoff, I. Uhlmann, M. Kaufmann, S. Brenner, and C. Werner. Dissecting the impact of matrix anchorage and elasticity in cell adhesion. Biophys J 97:2154-63 (2009). Link
  39. K. Franke, I. Kurth, M. Bornhäuser, C. Werner, and T. Pompe. Biomimetic Microcavities Based on Poly(dimethylsiloxane) Elastomers. Soft Matter 5:3505-10 (2009). Link
  40. D. Stamov, K. Salchert, A. Springer, C. Werner, and T. Pompe. Structural Polymorphism of Collagen Type I - Heparin Cofibrils. Soft Matter 5:3461-8 (2009). Link
  41. I. Kurth, K. Franke, T. Pompe, M. Bornhäuser, and C. Werner. Hematopoietic stem and progenitor cells in adhesive microcavities. Integr Biol 1:427-34 (2009). Link
  42. L. Renner, T. Pompe, and C. Werner. Electrostatic stretching of grafted maleic acid copolymer chains. Express Polym Lett 3:33-38 (2009). Link
  43. Z. Oezyuerek, K. Franke, M. Nitschke, R. Schulze, F. Simon, K. J. Eichhorn, T. Pompe, C. Werner, and B. Voit. Sulfated glyco-block copolymers with specific receptor and growth factor binding to support cell adhesion and proliferation. Biomaterials 30:1026-35 (2009). Link
  44. M. Herklotz, C. Werner, and T. Pompe. The impact of primary and secondary ligand coupling on extracellular matrix characteristics and formation of endothelial capillaries. Biomaterials 30:35-44 (2008). Link
  45. K. Alberti, R. E. Davey, K. Onishi, S. George, K. Salchert, F. P. Seib, M. Bornhauser, T. Pompe, A. Nagy, C. Werner, and P. W. Zandstra. Functional immobilization of signaling proteins enables control of stem cell fate. Nat Methods 5:645-50 (2008). Link
  46. L. Renner, T. Osaki, S. Chiantia, P. Schwille, T. Pompe, and C. Werner. Supported Lipid Bilayers on Spacious and pH-Responsive Polymer Cushions with Varied Hydrophilicity. J Phys Chem B 112:6373-78 (2008). Link
  47. D. Stamov, M. Grimmer, K. Salchert, T. Pompe, and C. Werner. Heparin intercalation into reconstituted collagen I fibrils: Impact on growth kinetics and morphology. Biomaterials 29:1-14 (2008). Link
  48. M. Herklotz, M. Melamed, C. Trautmann, M. Nitschke, T. Pompe, F. U. Gast, F. Howitz, and C. Werner. Non-contact printing of proteins on reactive polymer surfaces: a novel route towards structured and graded cell culture carriers. Microfluid Nanofluid 3:629-33 (2007). Link
  49. R. Grombe, M. F. Gouzy, M. F. Maitz, U. Freundenberg, S. Zschoche, F. Simon, T. Pompe, C. Sperling, and C. Werner. Sulfated glycopolymer thin films - preparation, characterization, and biological activity. Macromol Biosci 7:195-200 (2007). Link
  50. K. Franke, T. Pompe, M. Bornhauser, and C. Werner. Engineered matrix coatings to modulate the adhesion of CD133(+) human hematopoietic progenitor cells. Biomaterials 28:836-43 (2007). Link
  51. T. Pompe, K. Keller, G. Mothes, M. Nitschke, M. Teese, R. Zimmermann, and C. Werner. Surface modification of poly(hydroxybutyrate) films to control cell-matrix adhesion. Biomaterials 28:28-37 (2007). Link
  52. M. F. Gouzy, C. Sperling, K. Salchert, T. Pompe, C. Rauwolf, and C. Werner. Benzamidine-based coatings: Implication of inhibitor structure on the inhibition of coagulation enzymes in solution and in vitro hemocompatibility assessment. Biointerphases 1:146-55 (2006). Link
  53. T. Pompe, J. Starruss, M. Bobeth, and W. Pompe. Modeling of pattern development during fibronectin nanofibril formation. Biointerphases 1:93-97 (2006). Link
  54. T. Pompe, L. Renner, M. Grimmer, N. Herold, and C. Werner. Functional Films of Maleic Anhydride Copolymers under Physiological Conditions. Macromol Biosci 5:890-95 (2005). Link
  55. T. Pompe, K. Keller, C. Mitdank, and C. Werner. Fibronectin Fibril Pattern Displays the Force Balance of Cell-Matrix Adhesion  Eur Biophys J 34:1049-56 (2005). Link
  56. L. Renner, T. Pompe, K. Salchert, and C. Werner. Fibronectin Displacement at Polymer Surfaces. Langmuir 21:4571-77 (2005). Link
  57. T. Pompe, L. Renner, and C. Werner. Nanoscale Features of Fibronectin Fibrillogenesis Depend on Protein-Substrate Interaction and Cytoskeleton Structure. Biophys J 88:527-34 (2005). Link
  58. K. Salchert, U. Streller, T. Pompe, N. Herold, M. Grimmer, and C. Werner. In Vitro Reconstitution of Fibrillar Collagen Type I Assemblies at Reactive Polymer Surfaces. Biomacromolecules 5:1340-50 (2004). Link
  59. L. Renner, B. Jorgensen, M. Markowski, K. Salchert, C. Werner, and T. Pompe. Control o fibronectin displacement on polymer substrates to influence endothelial cell behaviour. J Mater Sci Mater Med 15:385-88 (2004). Link
  60. M. F. Gouzy, C. Sperling, K. Salchert, T. Pompe, U. Streller, P. Uhlmann, C. Rauwolf, F. Simon, F. Böhme, B. Voit, and C. Werner. In vitro blood compatibility of polymeric biomaterials through covalent immobilization of an amidine derivative. Biomaterials 25:3493-501 (2004). Link
  61. L. Renner, T. Pompe, K. Salchert, and C. Werner. Dynamic Alterations of Fibronectin Layers on Copolymer Substrates with Graded Physicochemical Characteristics. Langmuir 20:2928-33 (2004). Link
  62. T. Pompe, C. Mitdank, and C. Werner. Quantitative Analysis of Fibronectin Fibrillogenesis by Endothelial Cells on Biomaterials. J Phys: Cond Mat 16:S2421-S26 (2004). Link
  63. T. Pompe, M. Markowski, and C. Werner. Modulated Fibronectin Anchorage at Polymer Substrates Controls Angiogenesis. Tissue Eng 10:841-48 (2004). Link
  64. J. Oswald, B. Jorgensen, T. Pompe, F. Kobe, K. Salchert, M. Bornhauser, G. Ehninger, and C. Werner. Comparison of flow cytometry and laser scanning cytometry for the analysis of CD34+ hematopoietic stem cells. Cytometry 57A:100-07 (2004). Link
  65. K. Salchert, T. Pompe, C. Sperling, and C. Werner. Quantitative analysis of immobilized proteins and protein mixtures by amino acid analysis. J Chromatogr 1005:113-22 (2003). Link
  66. T. Pompe, F. Kobe, K. Salchert, B. Jorgensen, J. Oswald, and C. Werner. Fibronectin anchorage to polymer substrates controls the initial phase of endothelial cell adhesion. J Biomed Mater Res A 67:647-57 (2003). Link
  67. T. Pompe, S. Zschoche, N. Herold, K. Salchert, M. F. Gouzy, C. Sperling, and C. Werner. Maleic anhydride copolymers-a versatile platform for molecular biosurface engineering. Biomacromolecules 4:1072-79 (2003). Link
  68. T. Pompe. Line tension behavior of a first-order wetting system. Phys Rev Lett 89:076102 (2002). Link
  69. S. Herminghaus, T. Pompe, and A. Fery. Scanning Force Investigation of Liquid Structures and its Application to Fundamental Wetting Research. J Adh Sci Technol 14:1767-82 (2000). Link
  70. T. Pompe, and S. Herminghaus. Three-phase contact line energetics from nanoscale liquid surface topographies. Phys Rev Lett 85:1930-33 (2000). Link
  71. S. Herminghaus, A. Fery, S. Schlagowski, K. Jacobs, R. Seemann, H. Gau, W. Mönch, and T. Pompe. Liquid microstructures at solid interfaces. J Phys: Cond Mat 12:A57-A74 (2000). Link
  72. T. Pompe, A. Fery, and S. Herminghaus. Measurement of Contact Line Tension by Analysis of the Three-Phase Boundary with Nanometer Resolution. J Adhesion Sci Technol 13:1155-64 (1999). Link
  73. A. Fery, T. Pompe, and S. Herminghaus. Nanometer Resolution of Liquid Surface Topography by Scanning Force Microscopy. J Adhesion Sci Technol 13:1071-83 (1999). Link
  74. T. Pompe, A. Fery, A. Kriele, H. Lorenz, and J. P. Kotthaus. Submicron Contact Printing on Silicon Using Stamp Pads. Langmuir 15:2398-401 (1999). Link
  75. T. Pompe, S. Herminghaus, and A. Fery. Imaging Liquid Structures on Inhomogeneous Substrates by Scanning Force Microscopy. Langmuir 14:2585-88 (1998). Link
  76. T. Pompe, V. Srikant, and D. R. Clarke. Acoustoelectric current saturation in c-axis fiber-textured polycrystalline zinc oxide films. Appl Phys Lett 69:4065-67 (1996). Link
letzte Änderung: 12.09.2017


Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939

Petra Hartmann
Raum 1.34

Telefon: +49 341 97-36930
Telefax: +49 341 97-36939


New Paper on Soft Colloidal Probes in Further Biosensor Applications


A new paper of our group was published in Gels. In a collaborative study with Stephan Schmidt from Düsseldorf we explored new options for the...

New Paper on Myofibroblast Differentiation by Biomimetic Sustained Release of TGF-beta in 3D matrices


A paper of our group was just published online in Scientific Reports. In the study we demonstrate a low and sustained release TGF-beta1 from...

Our Paper Highlighted on Advanced Science News


Our recently published paper on macrophage polarization in 3D collagen matrices was highlighted on the Advanced Science News website as one of the...