Biophysikalische Chemie


Synthetic and naturally derived polymer matrices are utilized to analyze and control cell fate decisions in dependence on microenvironmental cues.

In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation.

Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies as well as regenerative therapies.

Furthermore, we apply polymer materials for new biosensor approaches ranging from soft colloids probes to nanoparticle assays to study weak receptor-ligand interactions and to detect small analytes.

letzte Änderung: 07.02.2018


Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939

Petra Zamzow
Raum 1.34

Telefon: +49 341 97-36930
Telefax: +49 341 97-36939


New Review Paper on Local Cytokine Release Systems


Based on the expertise gathered throughout his PhD work Michael Ansorge published a review article on local cytokine release systems to mimic...

New Paper on Kinetics and Topology of Fibrillar Collagen Networks


Our group published a new paper in Acta Biomaterialia. Therein we show that the kinetics of collagen I fibril formation as determined by turbidimetry...

New Paper on Tracking Primary Label-free Cells in Complex 3D Cell Culture Environments


Our group published a new paper in Scientific Reports. In a collaborative project with Mario Hlawitschka from HTWK Leipzig we developed a new method...