Biophysikalische Chemie


Synthetic and naturally derived polymer matrices are used to analyze and control cell fate decisions in dependence on microenvironmental cues.

In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation and transport.

Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies to reduce animal experiments.

In a second research area we apply bio-/polymer materials to develop biosensors for the detection of anthropogenic analytes in aqueous environments. The technologies are based on specific receptor-ligand interactions of functionalized hydrogel microparticles and nanoparticles.

letzte Änderung: 08.05.2018


Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939

Petra Zamzow
Raum 1.34

Telefon: +49 341 97-36930
Telefax: +49 341 97-36939


New Review Paper on Biomimetic Tumor Microenvironments


In a new paper Jiranuwat Sapudom reviews the current state-of-the-art article on engineering biomimetic 3D tumor microenvironments for in vitro...

New Review Paper on Local Cytokine Release Systems


Based on the expertise gathered throughout his PhD work Michael Ansorge published a review article on local cytokine release systems to mimic...

New Paper on Kinetics and Topology of Fibrillar Collagen Networks


Our group published a new paper in Acta Biomaterialia. Therein we show that the kinetics of collagen I fibril formation as determined by turbidimetry...