Biophysikalische Chemie

Mission

Synthetic and naturally derived polymer matrices are utilized to analyze and control cell fate decisions in dependence on microenvironmental cues.


In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation.


Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies as well as regenerative therapies.


Furthermore, we apply polymer materials for new biosensor approaches ranging from soft colloids probes to nanoparticle assays to study weak receptor-ligand interactions and to detect small analytes.

letzte Änderung: 19.04.2017

Kontakt

Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939
E-Mail

Sekretariat
Petra Hartmann
Raum 1.34

Telefon: +49 341 97-36930
Telefax: +49 341 97-36939
E-Mail

News

New Paper on Tracking Primary Label-free Cells in Complex 3D Cell Culture Environments

26.10.2017

Our group published a new paper in Scientific Reports. In a collaborative project with Mario Hlawitschka from HTWK Leipzig we developed a new method...

New Paper on Very Soft Single-Cell Hydrogel Microstructures for in vitro Applications

29.09.2017

We published a new paper in Advanced Materials. In a collaborative study with Carsten Werner from Dresden we designed in vitro cell culture scaffolds...

New Paper on Soft Colloidal Probes in Further Biosensor Applications

08.08.2017

A new paper of our group was published in Gels. In a collaborative study with Stephan Schmidt from Düsseldorf we explored new options for the...