Biophysikalische Chemie


Synthetic and naturally derived polymer matrices are utilized to analyze and control cell fate decisions in dependence on microenvironmental cues.

In a matrix engineering approach we design new biomimetic extracellular microenvironments by varying topology and mechanics of the matrix, distribution and mobility of ligands as well as the mode of cytokine presentation.

Based on the biophysical and biochemical characterization of these matrices and the induced cellular responses, we support a systemic understanding of exogenous cell signals, the development of in vitro assays for biomedical studies as well as regenerative therapies.

Furthermore, we apply polymer materials for new biosensor approaches ranging from soft colloids probes to nanoparticle assays to study weak receptor-ligand interactions and to detect small analytes.

letzte Änderung: 19.04.2017


Prof. Dr. Tilo Pompe
Universität Leipzig
Institute of Biochemistry
Johannisallee 21-23
04103 Leipzig

Telefon: +49 341 97-36931
Telefax: +49 341 97-36939

Petra Hartmann
Raum 1.34

Telefon: +49 341 97-36930
Telefax: +49 341 97-36939


New Paper on Myofibroblast Differentiation and Dedifferentiation in 3D Biomimetic Matrices


A paper of our group was just published online in Biomaterials Science. In the study we demonstrate collagen-based 3D matrices with temporal...

New Paper on Macrophage Polarization in 3D Collagen Networks


We just published a new paper in Advanced Healthcare Materials. Therein macrophage polarization is demonstrated to be controlled by elasticity and...

New Paper on CD44-dependent hyaluronan interaction


We just published a new paper online in Acta Biomaterialia. Therein we show the distinct CD44-dependent impact of hyaluronan at different molecular...