Publikationen

2017

Etzel, M., and Mörl, M. (2017) Synthetic Riboswitches – from Plug and Pray towards Plug and Play. Biochemistry, 56, No. 9, 1181-1198. doi: 10.1021/acs.biochem.6b01218

Abstract

Lorenz, C., Lünse, C., and Mörl, M. (2017) tRNA modifications: Impact on Structure and Thermal Adaptation. Biomolecules, 7, No. 2, pii: E35. doi: 10.3390/biom7020035

Abstract

Domin, G., Findeiß, S., Wachsmuth, M., Will, S., Stadler, P.F., and Mörl, M. (2017) Applicability of a Computational Design Approach for Synthetic Riboswitches. Nucleic Acids Res. 45, No. 7, 4108-4119. doi: 10.1093/nar/gkw1267Abstract
Findeiß, S., Etzel, M., Will, S., Mörl, M., Stadler, P.F. (2017) Design of Artificial Riboswitches as Biosensors. Sensors 17, 1990. doi: 10.3390/s17091990Abstract

2016

Franz, P., Betat, H., and Mörl, M. (2016) Genotyping bacterial and fungal pathogens using sequence variation in the gene for the CCA-adding enzyme. BMC Microbiology 16 (1), 47. doi: 10.1186/s12866-016-0670-2Abstract

2015

Betat, H., Mörl, M. (2015) The CCA-adding enzyme: a central scrutinizer in tRNA quality control. BioEssays 37, 975-982. doi: 10.1002/bies.201500043

Abstract

Betat, H., Mede, T., Tretbar, S., Steiner, L., Stadler, P.F., Mörl, M., and Prohaska, S.J. (2015) The Ancestor of Modern Holozoa Acquired the CCA-adding Enzyme from Alphaproteobacteria by Horizontal Gene Transfer. Nucleic Acids Res. 43, No. 14, 6739-6746. doi: 10.1093/nar/gkv631Abstract
Wende, S., Bonin, S., Götze, O., Betat, H., and Mörl, M. (2015) The Discriminator Position is important for CCA-Addition. Nucleic Acids Res. 43, No. 11, 5617-5629. doi: 10.1093/nar/gkv471Abstract
Wachsmuth, M., Domin, G.,  Lorenz, R., Serfling, R., Findeiß, S., Stadler, P., and Mörl, M. (2015) Design criteria for synthetic riboswitches acting on transcription. RNA Biol. 12, 221-231. doi: 10.1080/15476286.2015.1017235Abstract
Ernst, F.G.M., Rickert, C., Bluschke, A., Betat, H., Steinhoff, H.J., and Mörl, M. (2015) Domain movements during CCA addition: a new function for motif C in the catalytic core of the human tRNA nucleotidyltransferases. RNA Biol., 12, 435-446. doi: 10.1080/15476286.2015.1018502Abstract
Findeiß, S., Wachsmuth, M., Mörl, M. and Stadler, P.F. (2015) Design of transcription regulating riboswitches. Method Enzymol. 550, 1-22. doi: 10.1016/bs.mie.2014.10.029Abstract

2014

Betat, H., Long, Y.,  Jackmann, J.E. and Mörl, M.  (2014) From end to end: tRNA Editing at 5'- and 3'- terminal Positions. Int. J. Mol. Sci. 15, 23975-23998. doi: 10.3390/ijms151223975

Abstract

Wende, S., Platzer, E.G., Jühling, F., Pütz, J., Florentz, C., Stadler, P.F., and Mörl, M. (2014) Biological evidence for the world’s smallest tRNAs. Biochimie 100, 151-158. doi: 10.1016/j.biochi.2013.07.034Abstract

2013

Czech, A., Wende, S., Mörl, M., Pan, T., and Ignatova, Z. (2013) Reversible and Rapid Transfer-RNA Deactivation as a Mechanism of Translational Repression in Stress. PLoS Genet 9(8): e1003767. doi: 10.1371/journal.pgen.1003767

Abstract

Doose, G., Alexis, M., Kirsch, R., Findeiß, S., Langenberger, D., Machné, R., Mörl, M., Hoffmann, S., and Stadler, P.F. (2013) Mapping the RNA-Seq Trash Bin: Unusual Transcripts in Prokaryotic Transcriptome Sequencing Data. RNA Biol. 10, No. 7, 78-84. doi: 10.4161/rna.24972Abstract
Wachsmuth, M., Findeiß, Weissheimer, N., Stadler, P. F., and Mörl, M. (2013) De novo design of a synthetic riboswitch that regulates transcription termination. Nucleic Acids Res. 41, No. 4, 2541-2551 (featured article). doi: 10.1093/nar/gks1330Abstract

2012

Helm, M., Mörl, M., Stadler, P. F., and Hoffmann, S. (2012) Die nächste Generation der RNA Revolution – Deep Sequencing. Nachrichten aus der Chemie 3, 300.

 

Dickinson, H., Tretbar, S., Betat, H., and Mörl, M. (2012)  The TRAMP complex shows tRNA editing activity in S. cerevisiae. Mol. Biol. Evol. 29, No. 5, 1451-1459. doi: 10.1093/molbev/msr312Abstract
Wolf, J., Obermaier-Kusser, B., Jacobs, M., Milles, C., Mörl, M., von Pein, H.D., Bauer, M. F. (2012) A new mitochondrial point mutation in the transfer RNALys gene associated with progressive external ophthalmoplegia with impaired respiratory regulation. J. Neurol. Sci. 316, 108-111. doi: 10.1016/j.jns.2012.01.013Abstract

2011

Betat, H., and Mörl, M. (2011) CCA-addierende Enzyme: Hochspezifische RNA-Polymerasen mit ungewöhnlichen Eigenschaften. Biospektrum 05/2011510-513.

 

Tretbar, S., Neuenfeldt, A., Betat, H., and Mörl, M. (2011) An inhibitory C-terminal region dictates the specificity of A-adding enzymes. Proc. Natl. Acad. Sci. USA 108, No. 52, 21040-21045. doi: 10.1073/pnas.1116117108Abstract
Schütze, T., Wilhelm, B., Greiner, N., Braun, H., Peter, F., Mörl, M., Erdmann, V. A., Lehrach, H., Konthur, Z., Menger, M., Arndt, P. F., and Glökler, J. (2011) Probing the SELEX Process with next-generation Sequencing. PLoS One 6, No. 12, e29604. doi: 10.1371/journal.pone.0029604Abstract

2010

Hoffmeier, A., Betat, H., Bluschke, A., Günther, R., Sandy Junghanns, Hofmann, H.-J., and Mörl, M. (2010) Unusual Evolution of a Catalytic Core Element in CCA-adding Enzymes. Nucleic Acids Res. 38, No. 13, 4436-4447 doi: 10.1093/nar/gkq176

Abstract

Betat, H., Rammelt, C., and Mörl, M. (2010) tRNA Nucleotidyltransferases: Ancient Catalysts with an unusual Mechanism of Polymerization. Cell. Mol. Life Sci. 67 No. 9, 1447-1463 doi: 10.1007/s00018-010-0271-4Abstract
Vörtler, S., and Mörl, M. (2010) tRNA Nucleotidyltransferases: Highly unusual RNA Polymerases with vital Functions. FEBS Lett. 584(2), 297-302. doi: 10.1016/j.febslet.2009.10.078Abstract
Betat, H., and Mörl, M. (2010) tRNAs: Neue Funktionen für alte Bekannte. Labor & More 3.10, 22-25.

2009

Butter, F., Scheibe, M., Mörl, M., and Mann, M. (2009) Unbiased RNA-Protein Interaction Screen by quantitative Proteomics. Proc. Natl. Acad. Sci. USA, 106, 10626-10631. doi: 10.1073/pnas.0812099106

Abstract

Jühling, F., Mörl, M., Hartmann, R., Sprinzl, M., Stadler, P. F. and Pütz, J. (2009) tRNAdb 2009: Compilation of tRNA Sequences and tRNA Genes. Nucleic Acids Res. 37, D159-D162. doi: 10.1093/nar/gkn772Abstract

2008

Just, A., Butter, F., Trenkmann, M., Heitkam, T., Mörl, M. and Betat, H. (2008) A comparative analysis of two conserved motifs in bacterial poly(A) polymerase and CCA-adding enzyme. Nucleic Acids Res. 36, No. 16, 5212-5220. doi: 10.1093/nar/gkn494

Abstract

Neuenfeldt, A., Just, A., Betat, H. and Mörl, M. (2008) Evolution of tRNA Nucleotidyltransferases: A Small Deletion generated CC-Adding Enzymes. Proc. Natl. Acad. Sci. USA 105, No.23, 7953-7958. doi: 10.1073/pnas.0801971105 Abstract
Lizano-Gonzales, E., Scheibe, M., Rammelt, C., Betat, H. and Mörl, M. (2008) A Comparative Analysis of CCA-Adding Enzymes from Human and E. coli: Differences in CCA Addition and tRNA 3’-End Repair. Biochimie 90, 762-772. doi: 10.1016/j.biochi.2007.12.007Abstract
Hartmann, R. K., Mörl, M., and Willkomm, D. K. (2008) Contribution to the chapter "Ribozymes". Nucleic Acids from A to Z, VCH Wiley, 22-35

2007

Scheibe, M., Bonin, S., Hajnsdorf, E., Betat, H., and Mörl, M. (2007) Hfq stimulates the Activity of the CCA-adding Enzyme. BMC Mol. Biol. 8, 92 doi: 10.1186/1471-2199-8-92

Abstract

Lizano-Gonzales, E., Schuster, J., Müller, M., Kelso, J., and Mörl, M. (2007) A Splice variant of the human CCA adding Enzyme with modified Activity. J. Mol. Biol. 366, 1258-1265 doi: 10.1016/j.jmb.2006.12.016Abstract

2006

Lizano-Gonzales, E., and Mörl, M. (2006) tRNA. In: Encyclopedic Reference of Genomics and Proteomics in Molecular Medicine. Ganten, D., Ruckpaul, K. (Eds.), 1920-1924

 

2005

Mörl, M., Lizano, E., Willkomm, D. K., and Hartmann, R. K. (2005) Production of RNAs with Homogeneous 5’- and 3’-Ends. In: Handbook of RNA Biochemistry (Eds. R. K. Hartmann, A. Bindereif, A. Schön, E. Westhof) Wiley-VCH, 22-35

 

Schuster, J., Betat, H. and Mörl, M. (2005) Is yeast on its way to evolve tRNA editing? EMBO Reports 6, No. 4, 367-72. Corrigendum: EMBO Reports 6, No. 5, 487 doi: 10.1038/sj.embor.7400381Abstract

2004

Hartmann, R. K., Mörl, M., and Sprinzl, M. (2004) Meeting Report: The tRNA World. RNA 10, No.3, 344-349

Abstract

Levinger, L., Oestreich, I., Florentz, C., and Mörl, M. (2004) A pathogenesis-associated mutation in human mitochondrial tRNALeu(UUR) leads to reduced 3'-end processing and CCA addition. J. Mol. Biol. 337, No.3, 535-544 doi: 10.1016/j.jmb.2004.02.008Abstract
Schuster, J., and Mörl, M. (2004) Mitochondrial tRNA Editing. Top. Curr. Genet. 8, 81-96
Betat, H., Rammelt, C., Martin, G. and Mörl, M. (2004) Exchange of Regions between Bacterial Poly(A) Polymerase and CCA Adding Enzyme generates altered Specificities. Mol. Cell 15, 389-398 doi: 10.1016/j.molcel.2004.06.026Abstract
Levinger, L., Mörl, M., and Florentz, C. (2004) tRNA 3’ end metabolism and human mitochondrial disease. Nucleic Acids Res. 32, No.18, 5430-5441 doi: 10.1093/nar/gkh884Abstract

2003

Betat, H., and Mörl, M. (2003) tRNA Import in Mitochondrien. Biospektrum 1/2003, 33-35
Augustin, M., Reichert, A. S., Betat, H., Huber, R., Mörl, M., and Steegborn, C. (2003) Crystal Structure of the Human CCA-adding Enzyme: Insights into Template Independent Polymerisation. J. Mol. Biol. 328, No.5, 985-994 Abstract

2002

Schürer, H., Lang, K., Schuster, J., and Mörl, M. (2002) A universal Method to produce in vitro Transcripts with homogenous 3’- Ends. Nucl. Acids Res. 30, e56

Abstract

2001

Mörl, M., and Marchfelder, A. (2001) The final cut: The importance of tRNA 3’ processing. EMBO Rep. 2, No.1, 17-20 doi: 10.1093/embo-reports/kve006

Abstract

Schürer, H., Schiffer, S., Marchfelder, A., and Mörl, M. (2001) This is the End: Processing, Editing and Repair at the tRNA 3’-Terminus. Biol. Chem. 382, 1147-1156. doi: 10.1515/BC.2001.144Abstract
Dörner, M., Altmann, M., Pääbo, S., and Mörl, M. (2001) Evidence for Import of a lysyl-tRNA into Marsupial Mitochondria. Mol. Biol. Cell. 12, 2688-2698 Abstract
Reichert, A.S., Thurlow, D.L., and Mörl, M. (2001) A Eubacterial Origin for the Human tRNA Nucleotidyltransferase? Biol. Chem. 382, 1431-1438 doi: 10.1515/BC.2001.176Abstract

2000

Reichert, A.S., and Mörl, M. (2000) Repair of tRNAs in metazoan mitochondria. Nucl. Acids Res. 28, No.10, 2043-2048

Abstract

1998

Reichert, A., Rothbauer, U., and Mörl, M. (1998) Processing and Editing of Overlapping tRNAs in Human Mitochondria. J. Biol. Chem. 273, 31977-31984

Abstract

1997

Börner, G.V., Yokobori, S.-i., Mörl, M., Dörner, M., and Pääbo, S. (1997) RNA editing in metazoan mitochondria: staying fit without sex. FEBS Lett. 409, 320-324

Abstract

1996

Börner, G.V., Mörl, M., Janke, A., and Pääbo, S. (1996) RNA Editing Changes the Identity of a Mitochondrial tRNA in Marsupials. EMBO J. 15, 5949-5957

Abstract

1995

Börner, G.V., Mörl, M., Wissinger, B., Brennicke, A., and Schmelzer, C. (1995) RNA Editing of a Group II Intron in Oenothera as a Prerequisite for Splicing. Mol. Gen. Genet. 246, 739-744

Abstract

Mörl, M., Dörner, M., and Pääbo, S. (1995) C to U Editing and Modifications During the Maturation of the Mitochondrial tRNAAsp in Marsupials. Nucl. Acids Res. 23, No.17, 3380-3384 Abstract

1994

Mörl, M., Dörner, M., and Pääbo, S. (1994) Direct Purification of tRNAs Using Oligonucleotides Coupled to Magnetic Beads. Advances in Biomagnetic Separation, Eaton Publishing, Eds. M. Uhlén, E. Hornes, Ø. Olsvik, 107-111

 

1993

Mörl, M., and Schmelzer, C. (1993) A Simple Method for Isolation of Intact RNA from Dried Polyacrylamide Gels. Nucl. Acids Res. 21, No.8, 2016

Abstract

1992

Mörl, M., Niemer, I., and Schmelzer, C. (1992) New Reactions Catalyzed by a Group II Intron Ribozyme with RNA and DNA Substrates. Cell 70, 803-810

Abstract

1991

Wallasch, C., Mörl, M., Niemer, I., and Schmelzer, C. (1991) Structural Requirements for Selection of 5'- and 3'Splice Sites of Group II Introns. Nucl. Acids Res. 19, No.12, 3307-3314

Abstract

1990

Mörl, M., and Schmelzer, C. (1990) Integration of Group II Intron bI1 into a Foreign RNA by Reversal of the Self-Splicing Reaction In Vitro. Cell 60, 629-636

Abstract

Schmidt, U., Riederer, B., Mörl, M., Schmelzer, C., and Stahl, U. (1990) Self-Splicing of the Mobile Group II Intron of the Filamentous Fungus Podospora anserina (COI I1) In Vitro. EMBO J. 9, No.7, 2289-2298 Abstract
Mörl, M., and Schmelzer, C. (1990) Group II Intron RNA-Catalyzed Recombination of RNA In Vitro. Nucl. Acids. Res. 18, No. 22, 6545-6551 Abstract
letzte Änderung: 30.08.2017