Publikationen

2017

Franziska D. Zitzmann, Heinz-Georg Jahnke, Felix Nitschke, Annette G. Beck-Sickinger, Bernd Abel, Detlev Belder and Andrea A. Robitzki (2017). A novel microfluidic microelectrode chip for a significantly enhanced monitoring of NPY-receptor activation in live mode. Lab Chip. [Epub ahead of print] doi:10.1039/c7lc00754jAbstractPDF
Mario Schubert, Jan Stichel, Yu Du, Iain R. Tough, Gregory Sliwoski, Jens Meiler, Helen M. Cox, C. David Weaver and Annette G. Beck-Sickinger (2017). Identification and Characterization of the First Selective Y4 Receptor Positive Allosteric Modulator. J Med Chem. 60, 7605-7612AbstractPDF
Stefanie Schrottke, Anette Kaiser, Gerrit Vortmeier, Sylvia Els-Heindl, Dennis Worm, Mathias Bosse, Peter Schmidt, Holger A. Scheidt, Annette G. Beck-Sickinger and Daniel Huster (2017). Expression, Functional Characterization, and Solid-State NMR Investigation of the G Protein-Coupled GHS Receptors in Bilayer Membranes. Sci Rep. 7, 1-11

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Rares-Petru Moldovan, Sylvia Els-Heindl, Dennis J. Worm, Torsten Kniess, Michael Kluge, Annette G. Beck-Sickinger, Winnie Deuther-Conrad, Ute Krügel and Peter Brust (2017). Development of Fluorinated Non-Peptidic Ghrelin Receptor Ligands for Potential Use in Molecular Imaging. Int J Mol Sci. 5, 786-802AbstractPDF
Florent Jouy, Nadine Lohmann, Elke Wandel, Gloria Ruiz-Gómez, M. Teresa Pisabarro, Annette G. Beck-Sickinger, Matthias Schnabelrauch, Stephanie Möller, Jan C. Simon, Stefan Kalkhof, Martin von Bergen and Sandra Franz (2017). Sulfated hyaluronan attenuates inflammatory signaling pathways in macrophages involving induction of antioxidants. Proteomics. [Epub ahead of print] doi: 10.1002/pmic.201700082AbstractPDF
Ria Schönauer, Sylvia Els-Heindl and Annette G. Beck-Sickinger (2017). Adrenomedullin - new perspectives of a potent peptide hormone. J. Pept. Sci. [Epub ahead of print] doi:10.1002/psc.2953AbstractPDF
Kerstin Burkert, Tristan Zellmann, Rene Meier, Anette Kaiser, Jan Stichel, Jens Meiler, Gopi K. Mittapalli, Edward Roberts and Annette G. Beck-Sickinger (2017). A Deep Hydrophobic Binding Cavity is the Main Interaction for Different Y2R Antagonists. ChemMedChem. 12, 75-85AbstractPDF
Mareen Pagel and Annette G. Beck-Sickinger (2017). Multifunctional biomaterial coatings: synthetic challenges and biological activity. Biol. Chem. 398, 3-22AbstractPDF

Lizzy Wanka, Stefanie Babilon, Karin Mörl, Vsevolod V. Gurevich and Annette G. Beck-Sickinger (2016). C-terminal motif of human neuropeptide Y4 receptor determines internalization and arrestin recruitment. Cell Signal. 29, 233-239

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2016

Cathleen Juhl, Sylvia Els-Heindl, Ria Schönauer, Gordon Redlich, Erik Haaf, Frank Wunder, Bernd Riedl, Nils Burkhardt, Annette G. Beck-Sickinger and Donald Bierer (2016). Development of Potent and Metabolically Stable APJ Ligands with High Therapeutic Potential. ChemMedChem. 11, 2378–84AbstractPDF
Veronika Thieme, Navjeet Jolly, Andreas N. Madsen, Kathrin Bellmann-Sickert, Thue Schwartz, Birgitte Holst, Helen M. Cox and Annette G. Beck-Sickinger (2016). High molecular weight PEGylation of human pancreatic polypeptide at position 22 improves stability and reduces food intake in mice. Br. J. Pharmacol. 173, 3208-21AbstractPDF
Nydia Panitz, Stephan Theisgen, Sergey A. Samsonov, Jan-Philip Gehrcke, Lars Baumann, Kathrin Bellmann-Sickert, Sebastian Köhling, M Teresa Pisabarro, Jörg Rademann, Daniel Huster and Annette G. Beck-Sickinger (2016). The structural investigation of glycosaminoglycan binding to CXCL12 displays distinct interaction sites. Glycobiology. 26, 1209-21AbstractPDF
Cecilia Ratner, Louise J. Skov, Zindy Raida, Thomas Bächler, Kathrin Bellmann-Sickert, Christelle Le Foll, Bjørn Sivertsen, Louise S. Dalbøge, Bolette Hartmann, Annette G. Beck-Sickinger, Andreas N. Madsen, Jacob Jelsing, Jens J. Holst, Thomas A. Lutz, Zane B. Andrews and Birgitte Holst (2016). Effects of Peripheral Neurotensin on Appetite Regulation and Its Role in Gastric Bypass Surgery. Endocrinology. 157, 3482-92 AbstractPDF
Anika Gladytz, Torsten John, Thomas Gladytz, Rayk Hassert, Mareen Pagel, H. Jelger Risselada, Sergej Naumov, Annette G. Beck-Sickinger and Bernd Abel (2016). Peptides@mica: from affinity to adhesion mechanism. Phys. Chem. Chem. Phys. 18, 23516-27AbstractPDF
Ria Schönauer, Sylvia Els-Heindl, Jan-Patrick Fischer, Johannes Köbberling, Bernd Riedl and Annette G. Beck-Sickinger (2016). Adrenomedullin 2.0: Adjusting key levers for metabolic stability. J. Med. Chem. 12, 5695-705AbstractPDF
Gregory Sliwoski, Mario Schubert, Jan Stichel, David Weaver, Annette G. Beck-Sickinger and Jens Meiler (2016). Discovery of Small-Molecule Modulators of the Human Y4 Receptor. PLoS ONE, 11, 1-13AbstractPDF
Mareen Pagel, Rene Meier, Klaus Braun, Manfred Wiessler and Annette G. Beck-Sickinger (2016). On-resin Diels-Alder reaction with inverse electron demand: an efficient ligation method for complex peptides with a varying spacer to optimize cell adhesion. Org. Biomol. Chem. 14, 4809-16AbstractPDF
David Böhme, Jan Krieghoff and Annette G. Beck-Sickinger (2016). Double Methotrexate-modified Neuropeptide Y analogues express increased toxicity and overcome drug resistance in breast cancer cells. J. Med. Chem. 59, 3409-17AbstractPDF
Jonathan Lotze, Ulrike Reinhardt, Oliver Seitz and Annette G. Beck-Sickinger (2016). Peptide tags for site-specific protein labeling in vitro and in vivo. Mol. Biosyst. 12, 1731-45AbstractPDF
Dilip Verma, B. Hörmer, Kathrin Bellmann-Sickert, Veronika Theime, Annette G. Beck-Sickinger, Herbert Herzog, Günther Sperk and Ramon O Tasan (2016). Pancreatic polypeptide  and its central Y4 receptors are essential for cued fear extinction and permanent suppression. Br. J. Pharmacol. 173, 1925-38AbstractPDF
Sarah Zernia, Florian Ott, Kathrin Bellmann-Sickert, René Frank, Marcus Klenner, Heinz-Georg Jahnke, Andrea Prager, Bernd Abel, Andrea Robitzki and Annette G. Beck-Sickinger (2016). Peptide-mediated specific immobilization of catalytically active Cytochrome P450 BM3 variant. Bioconjug. Chem. 27, 1090-97AbstractPDF
Michael Ansorge, Nadine Rastig, Ralph Steinborn, Tina König, Lars Baumann, Staphanie Möller, Matthias Schnabelrauch, Michael Cross, Carsten Werner, Annette G. Beck-Sickinger and Tilo Pompe (2016). Short-range cytokine gradients to mimic paracrine cell interactions in vitro. J. Contr. Release 224, 59-68AbstractPDF
Mareen Pagel, Rayk Hassert, Torsten John, Klaus Braun, Manfred Wiessler and Annette G. Beck-Sickinger (2016). Multifunctional coating improves cell adhesion on titanium by using cooperatively acting peptides. Angew. Chem. Int. Ed. 55, 4826-30AbstractPDF
René Frank, Verena M. Ahrens, Solveig Boehnke, Annette G. Beck-Sickinger and Evamarie Hey-Hawkins (2016). Charge-compensated metallacarborane building blocks for conjugation with peptides. Chembiochem. 17, 308-17AbstractPDF
Jianxin Hu, Matthew Stern, Luis E. Diaz Gimenez, Lizzy Wanka, Lu Zhu, Mario Rossi, Annette G. Beck-Sickinger, Vsevolod V. Gurevich and Jürgen Wess (2016). A G-protein biased designer G-protein coupled receptor useful for studying the physiological relevance of Gq/11-dependent signaling pathways. J. Biol. Chem. 291, 7809-20AbstractPDF

Anja Saalbach, Jenny Anti-inflammatory action of keratinocyte-derived vaspin: relevance of the pathogenesis of psoriasis. 186

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Sylvia Els-Heindl, Kathrin Bellmann-Sickert and Annette G. Beck-Sickinger (2016). C-terminus of a hexapeptidic ghrelin receptor inverse agonist can switch peptide behaviour from inverse agonism to agonism. Biopolymers, 106, 101-8AbstractPDF
Cathleen Jendrny and Annette G. Beck-Sickinger (2016). Inhibition of kallikrein-related peptidases 7 and 5 by grafting serpin reactive center loop sequences onto sunflower trypsin inhibitor-1 (SFTI-1). Chembiochem. 17, 719-26AbstractPDF
Tom Marten Kilian, Nora Klöting, Matthias Blüher and Annette G. Beck-Sickinger (2016). Prenatal notch1 receptor blockade by protein delta homolog 1 (DLK1) modulates adipocyte size in vivo. Int. J. Obes. 40, 698-705AbstractPDF
Xuanzhi Zhan, Henriette Stoy, Tamer S. Kaoud, Niclos A. Perry, Qiuyan Chen, Alejandro Perez, Sylvia Els-Heindl, Jack V. Slagis, Tina M. Iverson, Annette G. Beck-Sickinger, Eugenia V. Gurevich, Kevin N. Dalby, Vsevolod V. Gurevich (2016). Peptide mini-scaffold facilitates JNK3 activation in cells. Sci. Rep. 6, 21025AbstractPDF

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2015

David Böhme and Annette G. Beck-Sickinger (2015). Drug delivery and release systems for targeted tumor therapy. J. Pept. Sci. 21, 186-200.AbstractPDF
René Frank, Verena Ahrens, Solveig Boehnke, Sven Hofmann, Martin Kellert, Stefan Saretz, Souvik Pandey, Menyhárt Sárosi, Ágota Bartók, Annette G. Beck-Sickinger and Evamarie Hey-Hawkins (2015)). Carbaboranes - more than just phenyl mimetics. Pure Appl. Chem. 87, 163-71.AbstractPDF
Ria Schönauer, Anette Kaiser, Cathleen Holze. Stefanie Babilon, Johannes Koebberling, Bernd Riedl and Annette G. Beck-Sickinger (2015). Flourescently labeled adrenomedullin allows realtime monitoring of adrenomedullin receptor trafficking in living cells. J. Pept. Sci. 21, 905-12.AbstractPDF
Minyoung Park, Bjørn B. Sivertsen, Sylvia Els-Heindl, Thomas Huber, Brigitte Holst, Annette G. Beck-Sickinger, Thue W. Schwartz and Thomas P. Sakmar (2015). Bioorthogonal labeling of ghrelin receptor to facilitate studies of ligand-dependent conformational dynamics. Chem. Biol.  22, 1431-36.AbstractPDF
Ulrike Reinhard, Jonathan Lotze, Karin Mörl, Annette G. Beck-Sickinger and Oliver Seitz (2015). Rapid covalent fluorescence labeling of membrane proteins on live cells via coiled-coil templated acyl-transfer. Bioconjug Chem. 26, 2106-17.AbstractPDF
Florian Job, Florian Settele, Susan Lorey, Chris Rundfeld, Lars Baumann, Annette G. Beck-Sickinger, Ulrich Haupts, Hauke Lilie and Eva Bosse-Doenecke (2015). Ubiquitin is a versatile scaffold protein for the generation of molecules with de novo binding and advantageous drug-like properties. FEBS Open Bio. 5, 579-593.AbstractPDF
Tom M. Kilian, Nora Klöting, Ralf Bergmann, Sylvia Els-Heindl, Stefanie Babilon, Mathieu Clement-Ziza, Yixin Zhang, Annette G. Beck-Sickinger and Constance Chollet. Rational design of dual peptides targeting Ghrelin and Y2 receptors to regulate food intake and body weight.J. Med. Chem. 58, 4180-93.AbstractPDF
Verena M. Ahrens, Katja B. Kostelnik, Robert Rennert, David Böhme, Stefan Kalkhof, David Kosel, Lutz Weber, Martin von Bergen and Annette G. Beck-Sickinger (2015) A cleavable cytolysin-neuropeptide Y bioconjugate enables specific drug delivery and demonstrates intracellular mode of action. J. Control Release 209, 170-178.AbstractPDF
Anette Kaiser, Paul Müller, Tristan Zellmann, Holger A. Scheidt, Lars Thomas, Mathias Bosse, Rene Meier, Jens Meiler, Daniel Huster, Annette G. Beck-Sickinger and Peter Schmidt (2015) Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation. Angew. Chemie Int. Ed. 54, 7446-7449.AbstractPDF
David Böhme and Annette G. Beck-Sickinger (2015) Controlling toxicity in peptide-drug conjugates by different chemical linker structures. ChemMedChem 10, 804-814.AbstractPDF
Gerrit Vortmeier, Stephanie H. DeLuca, Sylvia Els-Heindl, Constance Chollet, Holger A. Scheidt, Annette G. Beck-Sickinger, Jens Meiler and Daniel Huster (2015) Integrating Solid State NMR and Computational Modeling to Investigate the Structure and Dynamics of Membrane-Associated Ghrelin. PloS One 10, 3AbstractPDF
Sven Hofmann, Simone Maschauer, Torsten Kuwert, Annette Beck-Sickinger and Olaf Prante (2015) Synthesis, in vitro and in vivo evaluation of an 18F-labeled neuropeptide Y analog for imaging of breast cancer by PET. Mol. Pharmaceutics. 12, 1121-30.AbstractPDF
Tom-Marten Kilian and Annette G. Beck-Sickinger (2015) Recombinant Expression and Characterization of Biologically Active Protein Delta Homolog 1. Protein Expr. Purif. 110C, 72-78.AbstractPDF
Katja B. Kostelnik, Sylvia Els-Heindl, Nora Klöting, Sven Baumann, Martin von Bergen and Annette G. Beck-Sickinger (2015) High metabolic in vivo stability and bioavailability of a palmitoylated ghrelin receptor ligand assessed by mass spectrometry. Bioorg. Med. Chem. 23, 3925-32AbstractPDF
Verena M. Ahrens, Rene Frank, Solveig Boehnke, Christian L. Schütz, Gabriele Hampel, Dorothée S. Iffland, Nicolas H. Bings, Eva Hey-Hawkins and Annette G. Beck-Sickinger (2014) Receptor-mediated uptake of boron-rich neuropeptide Y analogs for boron neutron capture therapy. ChemMedChem 10, 164-72AbstractPDF
Jennifer M. Rojas, Eveline Bruinstroop, Richard L. Printz,Maxine K. Turney, Leena George, Annette G. Beck-Sickinger, Andries Kalsbeek and Kevin D. Niswender (2015) Central nervous system neuropeptide Y regulates mediators of hepatic phospholipid remodeling and very low density lipoprotein secretion via sympathetic innervation. Mol. Metab. 4, 210-21.AbstractPDF
Verena te Kamp, Heinz-Georg Jahnke, Dana Krinke, Katja Kostelnik, Annette G. Beck-Sickinger and Andrea A. Robitzki (2015) Quantitative impedimetric NPY-receptor activation monitoring and signal pathway profiling in living cells. Biosens. Bioelectronics. 67, 386-93. AbstractPDF

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2014

Veronika Mäde, Kathrin Bellmann-Sickert, Anette Kaiser, Jens Meiler and Annette G. Beck-Sickinger (2014) Position and length of fatty acids strongly affect receptor selectivity pattern of human pancreatic polypeptide analogues. ChemMedChem 9, 2463-74AbstractPDF
Ulrike Reinhardt, Jonathan Lotze, Sarah Zernia, Karin Mörl, Annette G. Beck-Sickinger and Oliver Seitz (2014) Peptide-templated acyl transfer: a chemical method for the labeling of membrane proteins. Angew. Chem. Int. Ed. 53,10237-41 AbstractPDF
Veronika Mäde, Stefanie Babilon, Navjeet Jolly, Lizzy Wanka, Kathrin Bellmann-Sickert, Luis E. Diaz Gimenez, Karin Mörl, Helen M. Cox, Vsevolod V. Gurevich and Annette G. Beck-Sickinger (2014) Peptide modifications differentially alter G protein-coupled receptor internalization and signaling bias. Angew. Chem. Int. Ed. 53, 10067-71AbstractPDF
Alexander Baer, Ivo de Sena Oliveira, Max Steinhagen, Annette G. Beck-Sickinger and Georg Mayer (2014) Slime protein profiling: a non-invasive tool for species identification in Onychophora (velvet worms). J. Zool. Syst. Evol. Res. 52, 265-272.AbstractPDF
Luiz E. Diaz Gimenez, Stefanie Babilon, Lizzy Wanka, Annette G. Beck-Sickinger and Vsevolod V. Gurevich (2014) Mutations in arrestin-3 differentially affect binding to neuropeptide Y receptor subtypes. Cell Signal. 26, 1523-31.AbstractPDF
Max Steinhagen, Peter-Georg Hoffmeister, Karoline Nordsieck, Rudi Hötzel, Lars Baumann, Michael Hacker, Michaela Schulz-Siegmund and Annette G. Beck-Sickinger (2014) Matrix metalloproteinase 9 (MMP-9) mediated release of MMP-9 resistant stromal cell-derived factor 1α (SDF-1α) from surface modified polymer films. ACS Appl. Mater. Interfaces. 6, 5891-99.AbstractPDF
Xavier Pedragosa-Badia, Gregory R. Sliwoski, Elizabeth Dong Nguyen, Diana Lindner, Jan Stichel, Kristian W. Kaufmann, Jens Meiler and Annette G. Beck-Sickinger (2014) Pancreatic polypeptide is recognized by two hydrophobic domains of the human Y4 receptor binding pocket. J. Biol. Chem. 289, 5846-59.AbstractPDF
Markus Gyger, Roland Stange, Tobias R. Kießling, Anatol Fritsch, Katja B. Kostelnik, Annette G. Beck-Sickinger, Mareike Zink and Josef A. Käs (2014) Active contractions in single suspended epithelial cells. Eur. Biophys. J. 43, 11-23. AbstractPDF

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2013

Kristin Möbius, Karoline Nordsieck, Annelie Pichert, Sergey A. Samsonov, Lars Thomas, Jürgen Schiller, Stefan Kalkhof, M. Teresa Pisabarro, Annette G. Beck-Sickinger and Daniel Huster (2013) Investigation of Lysine Side Chain Interactions of Interleukin-8 with Heparin and Other Glycosaminoglycans Studied by a Methylation-NMR Approach. Glycobiology 23,1260-9.AbstractPDF
Jana Breitfeld, John T. Heiker, Yvonne Böttcher, Dorit Schleinitz, Anke Tönjes, Kerstin Weidle, Kerstin Krause, E. Bartholomeus Kuettner, Markus Scholz, Wieland Kiess, Norbert Sträter, Annette G. Beck-Sickinger, Michael Stumvoll, Antje Körner, Matthias Blüher, Peter Kovacs (2013) Analysis of a Rare Functional Truncating Mutation rs61757459 in Vaspin (SERPINA12) on Circulating Vaspin Levels. J. Mol. Med. (Berl.) 91, 1285-92.AbstractPDF
Lars Baumann and Annette G. Beck-Sickinger (2013) Photoactivatable Chemokines – Controlling Protein Activity by Light. Angew. Chem. Int. Ed. Engl. 52, 9550-53.AbstractPDF
Kristina Witte, Anette Kaiser, Peter Schmidt, Victoria Splith, Lars Thomas, Sandra Berndt, Daniel Huster and Annette G. Beck-Sickinger (2013) Oxidative In Vitro Folding of a Cysteine Deficient Variant of the G Protein-coupled Neuropeptide Y Receptor Type 2 Improves Stability at High Concentration. Biol. Chem. 394, 1045-56. AbstractPDF
Daniel Rathmann, Xavier Pedragosa-Badia and Annette G. Beck-Sickinger (2013) In Vitro Modification of Substituted Cysteines as Tool to Study Receptor Functionality and Structure-activity Relationships. Anal. Biochem. 439, 173-83.AbstractPDF
Max Steinhagen, Katja Zunker, Karoline Nordsieck and Annette G. Beck-Sickinger (2013) Large Scale Modification of Biomolecules Using Immobilized Sortase A from Staphylococcus Aureus. Bioorg. Med. Chem. 21, 3504-10.AbstractPDF
Stephan Schultz, Anja Saalbach, John T. Heiker, René Meier, Tristan Zellmann, Jan C. Simon and Annette G. Beck-Sickinger (2013) Proteolytic Activation of Prochemerin by Kallikrein 7 Breaks an Ionic Linkage and Results in C-terminal Rearrangement. Biochem. J. 452, 271-80.AbstractPDF
John T. Heiker, Nora Klöting, Peter Kovacs, E. Bartholomeus Küttner, Norbert Sträter, Stephan Schultz, Matthias Kern, Michael Stumvoll, Matthias Blüher and Annette G. Beck-Sickinger (2013) Vaspin inhibits kallikrein 7 by serpin mechanism. Cell. Mol. Life Sci. 70, 2569-83.AbstractPDF
Sven Hofmann, Rene Frank, Eva Hey-Hawkins, Annette G. Beck-Sickinger, Peter Schmidt (2013) Manipulating Y Receptor Subtype Activation of Short Neuropeptide Y Analogs by Introducing Carbaboranes. Neuropeptides 47, 59-66.AbstractPDF
Volker Adams, John T. Heiker, Robert Höllriegel, Ephraim B. Beck, Felix J. Woitek, Sandra Erbs, Matthias Blüher, Michael Stumvoll , Annette G. Beck-Sickinger, Gerhard Schuler, Axel Linke (2013) Adiponectin Promotes the Migration of Circulating Angiogenic Cells Through p38-mediated Induction of the CXCR4 Receptor. Int. J. Cardiol. 167, 2039-46.AbstractPDF
Stephanie H. DeLuca, Daniel Rathmann, Annette G. Beck-Sickinger, Jens Meiler (2013) The Activity of Prolactin Releasing Peptide Correlates with its Helicity. Biopolymers 99, 314-325.AbstractPDF
Robert Spinnler, Theresa Gorski, Katharina Stolz, Susanne Schuster, Antje Garten, Annette G. Beck-Sickinger, Marten A. Engelse, Eelco J.P. de Koning, Antje Körner, Wieland Kiess and Kathrin Maedler (2013) The Adipocytokine Nampt and its Product NMN Have No Effect on Beta-Cell Survival but Potentiate Glucose Stimulated Insulin Secretion. PLoS ONE 8, e54106.AbstractPDF

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2012

Annelie Pichert, Sergey A. Samsonov, Stephan Theisgen, Lars Thomas, Lars Baumann, Jürgen Schiller, Annette G. Beck-Sickinger, Daniel Huster and M. Teresa Pisabarro (2012) Characterization of the Interaction of Interleukin-8 with Hyaluronan, Chondroitin Sulfate, Dermatan Sulfate, and their Sulfated Derivatives by Spectroscopy and Molecular Modelling, Glycobiology 22, 134-145.AbstractPDF
Anja Saalbach, Katharina Vester, Kathrin Rall, Jenny Tremel, Ulf Anderegg, Annette G. Beck-Sickinger, Matthias Blüher and Jan Simon (2012) Vaspin - a Link of Obesity and Psoriasis? Exp. Dermatol. 21, 309-312.AbstractPDF
Constance Chollet, Ralf Bergmann, Jens Pietzsch and Annette G. Beck-Sickinger (2012) Design, Evaluation, and Comparison of Ghrelin Receptor Agonists and Inverse Agonists as Suitable Radiotracers for PET Imaging Bioconjug. Chem. 23, 771-784.AbstractPDF
Lars Baumann, Silvana Prokoph, Christian Gabriel, Uwe Freudenberg, Carsten Werner and Annette G. Beck-Sickinger (2012) A Novel, Biased-like SDF-1 Derivative acts Synergistically with starPEG-based Heparin Hydrogels and improves eEPC Migration in vitro, J. Control. Release 162, 68-75.AbstractPDF
Cathleen Juhl, David Kosel and Annette G. Beck-Sickinger (2012) Two Motifs with Different Function Regulate the Anterograde Transport of the Adiponectin Receptor 1, Cell. Sign. 24, 1762-1769.AbstractPDF
J.C. Morales-Medina, S. Dominguez-Lopez, G. Gobbi, A.G. Beck-Sickinger and R. Quirion (2012) The Selective Neuropeptide Y Y5 agonist [cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP Differently Modulates Emotional Processes and Body Weight in the Rat, Behav. Brain Res. 233, 298-304.AbstractPDF
Maria Findeisen, Cäcilia Würker, Daniel Rathmann, René Meier,  Jens Meiler, Roger Olsson and Annette G. Beck-Sickinger (2012) Selective Mode of Action of Guanidine-Containing Non-Peptides at Human NPFF Receptors, J. Med. Chem. 55, 6124-6136AbstractPDF
Knut Kölbel,  Christian Ihling, Uwe Kühn, Ines Neundorf, Silke Otto, Jan Stichel, Dina Robaa, Annette G. Beck-Sickinger, Andrea Sinz and Elmar Wahle (2012) Peptide Backbone Conformation Affects the Substrate Preference of Protein Arginine Methyltransferase I,Biochemistry 51, 5463-5475.AbstractPDF
Daniel Rathmann, Diana Lindner, Stephanie H. DeLuca, Kristian W. Kaufmann, Jens Meiler and Annette G. Beck-Sickinger (2012) Ligand Mimicking Receptor Variant Discloses Binding and Activation Mode of Prolactin Releasing Peptide, J. Biol. Chem. 287, 32181-32194.AbstractPDF
Sylvia Els, Enrico Schild, Pia Steen Petersen, Tom-Marten Kilian, Jacek Mokrosinski, Thomas M. Frimurer, Constance Chollet, Thue W. Schwartz, Birgitte Holst and Annette G. Beck-Sickinger (2012) An Aromatic Region to Induce a Switch between Agonism and Inverse Agonism at the Ghrelin Receptor, J. Med. Chem. 55, 7437-7449.AbstractPDF
Sven Stadlbauer, René Frank, Matthias Scholz, Solveig Boehnke, Verena M. Ahrens, Annette G. Beck-Sickinger and Evamarie Hey-Hawkins (2012) Imitation and Modification of Bioactive Lead Structures via Integration of Boron Clusters, J. Pure Appl. Chem. 84, 2289-2298.AbstractPDF
Rayk Hassert, Mareen Pagel, Zhou Ming, Tilmann Häupl, Bernd Abel, Klaus Braun, Manfred Wiessler and Annette G. Beck-Sickinger (2012) Biocompatible Silicon Surfaces through Orthogonal Click Chemistries and a High Affinity Silicon Oxide Binding Peptide. Bioconj. Chem. 23, 2129-2137.AbstractPDF
Karoline Nordsieck, Annelie Pichert, Sergey A. Samsonov, Lars Thomas, Christian Berger, M. Teresa Pisabarro, Daniel Huster and Annette G. Beck-Sickinger (2012) Residue 75 of Interleukin 8 is Crucial for its Interaction with Glucosaminoglycans. ChemBioChem 13, 2558-2566.AbstractPDF
Jennifer M. Rojas, John M. Stafford , Sanaz Saadat, Richard L. Printz, Annette G. Beck-Sickinger and Kevin D. Niswender (2012) Central Nervous System Neuropeptide Y Signaling via the Y1 receptor Partially Dissociates Feeding Behavior from Lipoprotein Metabolism in Lean Rats. Amer. J. Physiol. Endocrin. Metabol. 303, E1479-1488.Abstract
Rayk Hassert, Peter-Georg Hoffmann, Mareen Pagel, Michael Hacker, Michaela Schulz-Siegmund and Annette Beck-Sickinger (2012) On-Resin Synthesis of An Acylated and Fluorescence-Labeled Cyclic Integrin Ligand for Modification of Poly(lactic-co-glycolic acid). Chem. Biodivers. 9, 2648-2658.AbstractPDF
Cornelia Walther, Jonathan Lotze, Annette G. Beck-Sickinger and Karin Mörl (2012) The Anterograde Transport of the Human Neuropeptide Y2 Receptor is regulated by a Subtype Specific Mechanism Mediated by the C-Terminus. Neuropeptides 46, 335-343.AbstractPDF

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2011

Matthias Scholz, Max Steinhagen, John T. Heiker, Annette G. Beck-Sickinger, Evamarie Hey-Hawkins (2011) Asborin inibits Aldo/Keto Reductase 1A1, ChemMedChem.6, 89-93. AbstractPDF
Kathrin Bellmann-Sickert and Annette G. Beck-Sickinger (2011) Palmitoylated SDF1α Shows Increased Resistance Against Proteolytic Degradation in Liver Homogenates, ChemMedChem.6, 193-200.AbstractPDF
Verena M. Ahrens, René Frank, Sven Stadlbauer, Annette G. Beck-Sickinger, Evamarie Hey-Hawkins (2011) Incorporation of ortho-Carbaboranyl-Nε-modified L-Lysine into Neuropeptide Y Receptor Y1- and Y2-Selective Analogues, J. Med. Chem. 54, 2368-2377.AbstractPDF
Kathrin Bellmann-Sickert, Christian Elling, Andreas Nygaard Madsen, Paul B. Little, Karsten Lundgren, Lars-Ole Gerlach, Ralf Bergmann, Birgitte Holst, Thue W. Schwartz, Annette G. Beck Beck-Sickinger (2011) Long-acting Lipidated Analogue of Human Pancreatic Polypeptide is Slowly Released into Circulation,  J. Med. Chem. 54, 2658-67AbstractPDF
Maria Findeisen, Daniel Rathmann, Annette G. Beck-Sickinger (2011) Structure/Activity Studies of RFamides Reveal a Subtype Specific Activation of Neuropeptide FF1 and FF2 Receptors, ChemMedChem. 6, 1081-1093.AbstractPDF
Bjørn Sivertsen, Manja Lang, Thomas M.Frimurer, Anders Bach, Sylvia Els, Maja S.Engelstoft, Thue W. Schwartz, Annette G. Beck-Sickinger and Birgitte Holst (2011) Unique Interaction Pattern for a Functionally Biased Ghrelin Receptor Agonist, J. Biol. Chem. 286, 20845-60AbstractPDF
Nora Klöting, Peter Kovacs, Matthias Kern, John T. Heiker, Jana Breitfeld, Joanna Kosacka, Michael Stumvoll, Annette G. Beck-Sickinger , Matthias Blüher (2011) Central Vaspin Administration Acutely Reduces Food Intake and has Sustained Blood Glucose-lowering Effects, Diabetiologica 54, 1819-23AbstractPDF
Cathleen Juhl, Karin Mörl, Annette G. Beck-Sickinger (2011) Adiponectin Receptor 1 Interacts with Both Subunits of Protein Kinase CK2, Mol. Cell. Biochem. 356, 185-189AbstractPDF
Claire Jones, Jonas Denecke, Ronald Sträter, Torsten Stölting, Yvonne Schunicht, Dagmar Zeuschner, Judith Klumperman, Dirk J. Lefeber, Oliver Spelten, Alexander Zarbock, Sørge kelm, Karen Strenge, Stuart M. Haslam, Kerstin Lühn, Dorothea Stahl, Luca Gentile, Thomas Schreiter, Philip Hilgard, Annette G. Beck-Sickinger, Thorsten Marquart and Martin K. Wild (2011) A Novel Type of Macrothrombocytopenia Associated with a Defect in α2,3-Sialylation, Am. J. Path. 179, 1969-77AbstractPDF
Max Steinhagen, Kai Holland-Nell, Morten Meldal and Annette G. Beck-Sickinger (2011) Simultaneous "One Pot" Expressed Protein Ligation and CuI-Catalyzed Azide/Alkyne Cycloaddition for Protein Immobilization, ChemBioChem. 12, 2426-30AbstractPDF
Mathias Bosse, Lars Thomas, Rayk Hassert, Annette G. Beck-Sickinger, Daniel Huster and Peter Schmidt (2011) Assessment of a Fully Active Class A G Protein-Coupled Receptor Isolated from in Vitro Folding, Biochemistry 50, 9817-25. AbstractPDF

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2010

Irfan U. Khan, Denise Zwanziger, Ilka Böhme, Muhammad Javed, Hamid Naseer, Syed W. Hyder, Annette G. Beck-Sickinger (2010) Breast cancer diagnosis by neuropeptide Y analogues - first clinical approach, Angew. Chem. Int. Ed. 49, 1155-1158. (VIP-Paper).AbstractPDF
Susann Schimmer, Diana Lindner, Peter Schmidt, Annette G. Beck-Sickinger, Daniel Huster, Rainer Rudolph (2010) Functional characterization of the in vitro folded human Y1 receptor in lipid environment, Protein Pept. Lett. 17, 605-609. AbstractPDF
David Kosel, John Heiker, Cathleen Juhl, Cornelia Deckert, Matthias Blüher, Karin Mörl, Annette G. Beck-Sickinger (2010) Adiponectin receptor 1 dimerisation is inhibited by adiponectin, J. Cell. Sci. 123, 1320-1328.AbstractPDF
Peter Schmidt, Christian Berger, Holger A. Scheidt, Sandra Berndt, Andreas Bunge, Annette G. Beck-Sickinger, and Daniel Huster (2010),  A Reconstitution Protocol for the in vitro Folded Human G Protein-Coupled Y2 Receptor into Lipid Environment, Biophys. Chem. 150, 29-36.AbstractPDF
John T. Heiker, Nora Klöting, Matthias Blüher, Annette G. Beck-Sickinger (2010) Access to gram scale amounts of functional globular adiponectin from E. coli inclusion bodies by alkaline-shock solubilization, Biophys. Biochem. Res. Comm. 398,  32-37.AbstractPDF
Kathrin Bellmann-Sickert, Lars Baumann, Annette G. Beck-Sickinger (2010) Selective labelling of stromal cell-derived factor 1α with carboxyfluorescein to study receptor internalisation, J. Pept. Sci. 16, 568-574.AbstractPDF
Michael Bachmann, Karsten Goede, Annette G. Beck-Sickinger, Marius Grundmann, Anders Irbäck, Wolfhard Janke (2010) Microscopic Mechanism of Specific Peptide Adhesion to Semiconductor Substrates, Angew. Chem, Int. Ed. 49, 9530-9533.AbstractPDF
Lars Baumann, Annette G. Beck-Sickinger (2010) Identification of a potential modification site of stromal-derived factor 1, Biopolymers 94, 771-778.AbstractPDF
Cornelia Walther, Stefanie Nagel, Luis E. Gimenez, Karin Mörl, Vsevolod V. Gurevich, Annette G. Beck-Sickinger (2010) Ligand induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its C-terminal tail, J. Biol. Chem. 285, 41578-41590.AbstractPDF

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2009

Diana Lindner, Cornelia Walther, Anja Tennemann and Annette G. Beck-Sickinger (2009) Functional role of the extracellular N-terminal domain of Neuropeptide Y subfamily receptors in membrane integration and agonist-stimulated internalisation, Cell. Signal. 21, 61–68.AbstractPDF
Knut Kölbel, Christian Ihling, Kathrin Bellmann-Sickert, Ines Neundorf, Annette G. Beck-Sickinger, Andrea Sinz, Uwe Kühn and Elmar Wahle (2009) Type I arginine methyl transferases PRMT1 and 3 act distributively, J. Biol. Chem. 284, 8274-8282.AbstractPDF
John T. Heiker, Cornelia M. Wottawah, Cathleen Juhl, David Kosel, Karin Mörl and Annette G. Beck-Sickinger (2009) Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signalling, Cell. Signal. 21, 936-942.AbstractPDF
Lars Thomas, Holger A. Scheidt, Andrea Bettio, Annette G. Beck- Sickinger, Daniel Huster and Olaf Zschörnig (2009) The Interaction of Neuropeptide Y with Negatively Charged and Zwitterionic Phospholipid Membrane, Eur. Biophys.  J. 38, 663-77.AbstractPDF
Michael Haack, Annette G. Beck-Sickinger (2009) Towards understanding the free and receptor bound conformation of neuropeptide Y by fluorescence resonance energy transfer studies, Chem. Biol. Drug Design 73, 573-583.AbstractPDF
Pia Steen Petersen, David P.D. Woldbye, Andreas Nygaard Madsen, Kristoffer L Egerod, Chunyu Jin, Manja Lang, Annette G.Beck-Sickinger, and Birgitte Holst (2009) In Vivo Characterization of High Basal Signaling from the Ghrelin Receptor, Endocrinology 150,4920-30.Abstract
Denise Zwanziger, Ilka Böhme, Diana Lindner and Annette G. Beck-Sickinger (2009) The First Selective Agonist of the Neuropeptide Y1-Receptor with Reduced Size, J. Pept. Sci. 15, 856-866.AbstractPDF
Peter Schmidt, Diana Lindner, Cindy Montag, Sandra Bertsch, Annette G. Beck-Sickinger; Rainer Rudolph, Daniel Huster (2009) Prokaryotic expression, in vitro folding, and molecular pharmacological characterisation of the neuropeptide Y receptor type 2, Biotechnol. Progr. 25, 1732-1739. AbstractPDF

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2008

Keller M, Pop N, Hutzler C, Beck-Sickinger AG, Bernhardt G, Buschauer A. (2008) Guanidine-acylguanidine bioisosteric approach in the design of radioligands: synthesis of a tritium-labeled N(G)-propionylargininamide ([3H]-UR-MK114) as a highly potent and selective neuropeptide Y Y1 receptor antagonist. J. Med. Chem. 51, 8168-72.AbstractPDF
David R, Günther R, Baumann L, Lühmann T, Seebach D, Hofmann HJ, Beck-Sickinger AG. (2008) Artificial chemokines: combining chemistry and molecular biology for the elucidation of interleukin-8 functionality. J. Am. Chem. Soc. 130, 15311-7.AbstractPDF
Chee MJ, Mörl K, Lindner D, Merten N, Zamponi GW, Light PE, Beck-Sickinger AG, Colmers WF. (2008) The third intracellular loop stabilizes the inactive state of the neuropeptide Y1 receptor. J. Biol. Chem. 283, 33337-46.AbstractPDF
Böhme I, Stichel J, Walther C, Mörl K, Beck-Sickinger AG. (2008) Agonist induced receptor internalization of neuropeptide Y receptor subtypes depends on third intracellular loop and C-terminus. Cell. Signal. 20, 1740-9.AbstractPDF
Lindner D, Günther R, van Dieck J, Merten N, Mörl K, Hofmann HJ, Beck-Sickinger AG. (2008) GPC-Receptors, not Ligands decide on binding mode in neuropeptide Y multi-receptor/multi-ligand system, Biochemistry, 47, 5905-14.AbstractPDF
Fronz K, Otto S, Kölbel K, Kühn U, Friedrich H, Schierhorn A, Beck-Sickinger AG, Ostareck-Lederer A, Wahle E (2008) Promiscuous modification of the nuclear poly(A)-binding protein by multiple protein-arginine methyltransferases does not affect the aggregation behavior. J. Biol. Chem. 283, 20408-20.AbstractPDF
Wolf P, Rothermel A, Beck-Sickinger AG, Robitzki AA (2008) Microelectrode chip based real time monitoring of vital MCF-7 mamma carcinoma cells by impedance spectroscopy. Biosens. Bioelectron. 24, 253-9.AbstractPDF
Zwanziger D, Khan IU, Neundorf I, Sieger S, Lehmann L, Friebe M, Dinkelborg L, Beck-Sickinger AG (2008) Novel chemically modified analogues of neuropeptide Y for tumor targeting. Bioconjug. Chem. 19, 1430-8.Abstract
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Haack M, Enck S, Seger H, Geyer A, Beck-Sickinger AG. (2008) Pyridone dipeptide backbone scan to elucidate structural properties of a flexible peptide segment. J. Am. Chem. Soc. 130, 8326-36.AbstractPDF
David Frommhold, Andreas Ludwig, M. Gabriele Bixel, Alexander Zarbock, Inna Babushkina, Melitta Weissinger, Sandra Cauwenberghs, Bärbel Lange-Sperandio, Lesley G. Ellies, Jamey D. Marth, Annette G. Beck-Sickinger, Alma Zernecke, Christian Weber, Dietmar Vestweber, Klaus Ley, and Markus Sperandio (2008) Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation, J. Exp. Med. 205, 1435-46.AbstractPDF
Löw C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J (2008) Structure and dynamics of Helix-0 of the N-BAR domain in Lipid Micelles and Bilayers. Biophys. J. 95, 4315-23.AbstractPDF
Rennert R, Neundorf I, Jahnke HG, Suchowerskyj P, Dournaud P, Robitzki A, Beck-Sickinger AG (2008) Generation of carrier peptides for the delivery of nucleic acid drugs in primary cells. ChemMedChem. 3, 241-53.AbstractPDF
Singer D, Herth N, Kuhlmann J, Holland-Nell K, Beck-Sickinger AG, Hoffmann R (2008) Mapping of phosphorylation-dependent anti-Tau monoclonal antibodies in immunoblots using human tau-constructs synthesized by native chemical ligation, Biochem. Biophys. Res. Comm. 367, 318-22AbstractPDF

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2007

Birgitte Holst, Kristoffer Egerod, Enrico Schild, Lars-Ole Gerlach, Carsten E. Stiedsen, Annette G. Beck-Sickinger & Thue W. Schwartz (2007) GPR39 Signaling is stimulated by Zinc ions but not by Obestatin. Endocrinology 148, 13-20.AbstractPDF
Ralf David and Annette G. Beck-Sickinger (2007) Identification of the dimerisation interface of human interleukin-8 by IL-8-variants containing the photoactivatable amino acid benzoyl-phenylalanine. Eur. Biophys. J. 36, 385-91.AbstractPDF
Elisa García Garayoa, Dominique Rüegg, Peter Bläuenstein, Martin Zwimpfer, Irfan Ullah Khan, Veronique Maes, Alain Blanc, Annette G. Beck-Sickinger, Dirk A. Tourwé and P. August Schubiger (2007) Chemical and biological characterization of new Re(CO)3/[99mTc](CO)3 bombesin analogues. Nucl. Med. Biol. 34, 17-28.AbstractPDF
Nicole Merten, Diana Lindner, Nadine Rabe, Holger Römpler, Karin Mörl, Torsten Schöneberg, Annette G. Beck-Sickinger (2007) Receptor Subtype Specific Docking of Asp6.59 with C-terminal Arginine Residues in Y-Receptor Ligands. J. Biol. Chem. 282, 7543-51.AbstractPDF
Ilka Böhme, Karin Mörl, Darja Bamming, Cindy Meyer, Annette G. Beck-Sickinger (2007) Tracking of human Y receptors in living cells – a fluorescence approach. Peptides 28, 226-34.AbstractPDF
Franka Pluder, Annette G. Beck-Sickinger (2007) One step procedure for staining of 2D-gels with ruthenium II tris (bathophenanthroline disulfonate). Anal. Biochem. 361, 299-301.AbstractPDF
Margaret J. Morris, Emma Gannan, Leanne M Stroud, Annette G. Beck-Sickinger and Terence J O’Brien, (2007) Neuropeptide Y suppresses absence of seizures in a genetic rat model primarily through effects on Y2 receptors, Eur. J. Neurosci. 25, 1136-43.AbstractPDF
Franka Pluder, Andrea Sinz and Annette G. Beck-Sickinger (2007) Proliferative effect of calcitonin gene-related peptide is induced by at least five proteins as identified by proteome profiling. Chem. Biol. Drug Des.  69, 14-22.AbstractPDF
Elisa García Garayoa, G. Schweinsberg, Veronique Maes, Dominique Rüegg, Alain Blanc, Peter Bläuenstein, Dirk A. Tourwé, Annette G. Beck-Sickinger, and P. August Schubiger (2007) New [99mTc] bombesin analogues with improved biodistribution for targeting gastrin releasing-peptide receptor-positive tumors. Q. J. Nucl. Med. Mol. Imaging 51, 42-50.AbstractPDF
Irfan U. Khan, Regina Reppich, Annette G. Beck-Sickinger (2007) Identification of Neuropeptide Y Cleavage Products in Human Blood tom Improve Metabolic Stability. Biopolymers 88, 182-9.AbstractPDF
Birgitte Holst, Jacek Mokrosinski, Manja Lang, Erik Brandt, Annette G. Beck-Sickinger, Thue W. Schwartz (2007) Identification of an efficacy switch region in the ghrelin receptor responsible for interchange between agonism and inverse agonism. J. Biol. Chem. 282, 15799-15811.AbstractPDF
Kai Holland-Nell, Annette G. Beck-Sickinger (2007) Specifically immobilised aldo/keto reductase AKR1A1 shows dramatic increase in activity compared to randomly immobilized enzyme, Chembiochem. 8, 1071-6.AbstractPDF
Ralf Ziemek, Erich Schneider,  Anja Kraus,  Chiara Cabrele, Annette G. Beck-Sickinger,  Günther Bernhardt, Armin Buschauer (2007) Determination of Affinity and Activity of Ligands at the Human Neuropeptide Y Y4 Receptor by Flow Cytometry and Aequorin Luminescence,  J. Recept. Signal. Transduct. Res. 27, 217–233.AbstractPDF

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2006

Manja Lang, Silvia De Pol, Carsten Baldauf, Hans-Jörg Hofmann, Oliver Reiser and Annette G. Beck-Sickinger (2006) Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor, J. Med. Chem. 49, 616-24.AbstractPDF
Manja Lang, Bernd Bufe, Silvia de Pol, Oliver Reiser, Wolfgang Meyerhof and Annette G. Beck-Sickinger (2006) Structural properties of orexins for activation of their receptors, J. Pept. Sci. 12, 258-66.AbstractPDF
Paulus, T., Riemer, C., Beck-Sickinger, A. G., Henle, T., Klostermeyer, H. (2006), Protein-backbone-modifications: Formation of imidazolines. Eur. Food Res. & Techn. 222, 242-9AbstractPDF
Ortrud Uckermann, Antje Wolf, Franziska Kutzera, Folke Kalisch, Annette G. Beck-Sickinger, Peter Wiedemann, Andreas Reichenbach and Andreas Bringmann (2006) Glutamate Release by Neurons Evokes a Purinergic Inhibitory Mechanism of Osmotic Glial Cell Swelling in the Rat Retina. Activation by Neuropeptide Y, J. Neurosci. Res., 83, 538-50.AbstractPDF
Robert Rennert, Christian Wespe, Annette G. Beck-Sickinger, Ines Neundorf (2006) Developing novel hCT derived cell-penetrating peptides with improved metabolic stability, Biochim. Biophys. Acta, 1758, 347-54.AbstractPDF
Christian Ihling, Andreas Schmidt, Stefan Kalkhof, Christoph Stingl, Karl Mechtler, Michael Haack, Daniela M. Schulz, Dermot M. F. Cooper, Annette G. Beck-Sickinger and Andrea Sinz (2006) Isotope-Labeled Cross-Linkers and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Structural Analysis of a Protein / Peptide Complex, J. Am. Soc. Mass Spectrom. 17, 1100-13.AbstractPDF
K. Goede, M. Grundmann, K. Holland-Nell, A. G. Beck-Sickinger (2006) Cluster properties of peptides on (100) semiconductor surfaces, Langmuir 22, 8104-8.AbstractPDF
Birgitte Holst, Manja Lang, Erik Brandt, Anders Bach, Andrew Howard, Thomas M. Frimurer, Annette Beck-Sickinger, Thue W. Schwartz (2006) Ghrelin Receptor Inverse Agonists - Identification of an Active Peptide Core and its Interaction Epitopes on the Receptor, Mol. Pharmacol. 70, 936-46.AbstractPDF
Mette M. Rosenkilde, Ralf David, Ilka Oerlecke, Ulf Geumann, Annette G. Beck-Sickinger and Thue W. Schwartz (2006) Conformational constraining of inactive and active states of a 7TM receptor by metal-ion site engineering in the top of TM 5. Mol. Pharmacology 70, 1892-1901AbstractPDF
Ralf Ziemek, Albert Brennauer, Erich Schneider, Chiara Cabrele, Annette G. Beck-Sickinger, Günther Bernhardt, Armin Buschauer (2006) Fluorescence- and luminescence-based methods for the determination of affinity and activity of neuropeptide Y Y2 receptor ligands. Eur. J. Pharmacol. 551, 10-18.AbstractPDF
Krause K, Schierhorn A, Sinz A, Wissmann JD, Beck-Sickinger AG, Paschke R, Fuhrer D. (2006) Toward the application of proteomics to human thyroid tissue, Thyroid 16,  1131-43AbstractPDF
Cornelia M. Deckert, John T. Heiker, Annette G. Beck-Sickinger (2006) Localization of Novel Adiponectin Receptor Constructs. J. Recept. Signal. Transduct. Res. 26, 647-57.AbstractPDF

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2005 und älter

Dimitrijevic M, Stanojevic S, Vujic V, Beck-Sickinger A, von Horsten S  (2005) Neuropeptide Y and its receptor subtypes specifically modulate rat peritoneal macrophage functions in vitro: counter regulation through Y1 and Y2/5 receptors. Regul. Pept. 124, 163-72.AbstractPDF
R. Benmaamar, C. Richichi, M. Gobbi, A. J. Daniels, A. G. Beck-Sickinger, A. Vezzani (2005) Neuropeptide Y Y5 receptors mediate inhibition of kindling acquisition in rats, Regul. Pept. 125, 79-83.AbstractPDF
Klammt J., Garten A., Barnikol-Oettler A., Beck-Sickinger A. G., Kiess. W. (2005) Comparative analysis of the signalling capabilities of the insulin receptor related receptor, Biochem. Biophys. Res. Commun. 327, 557-64.AbstractPDF
Christina Foerg, Urs Ziegler, Jimena Fernandez-Carneado, Ernest Giralt, Robert Rennert, Annette G. Beck-Sickinger, Hans P. Merkle (2005) Decoding the entry of two novel cell penetrating peptides in HeLa cells: lipid-raft mediated endocytosis and endosomal escape, Biochemistry 44, 72-81.AbstractPDF
Howell O. W., Doyle K., Goodman J. H., Scharfman H. E., Herzog H., Pringle A., Beck-Sickinger A. G., Gray W. P. (2005) Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus, J. Neurochem. 93, 560-70.AbstractPDF
Michael E. Herbig, Ursina Fromm, Jeannine Leuenberger, Ulrike Krauss, Annette G. Beck-Sickinger, and Hans P. Merkle (2005) Bilayer interaction and localization of cell penetrating peptides with model membranes: A comparative study of a human calcitonin (hCT) derived peptide with pVEC and pAntp(43-58), Biochim. Biophys. Acta. 1712, 197-211.AbstractPDF
Mirjam Lerch, Hiroshi Kamimori, Gerd Folkers, Marie-Isabel Aguilar, Annette G. Beck-Sickinger, and Oliver Zerbe (2005) Strongly Altered Receptor Binding Properties in PP and NPY Chimeras Are Accompanied by Changes in Structure and Membrane Binding, Biochemistry 44, 9255-64.AbstractPDF
Michael P. O. Richter, Annette G. Beck-Sickinger (2005) Expressed Protein Ligation for the Semisynthesis of Modified Aldo/ketoreductases, Pept. Prot. Lett. 12, 777-81. AbstractPDF
Bouchaïb El Bahh, Silvia Balosso, Trevor Hamilton, Herbert Herzog, Annette G. Beck-Sickinger, Günther Sperk, Donald R. Gehlert, Annamaria Vezzani and William F. Colmers (2005) The antiepileptic actions of neuropeptide Y in the hippocampus are mediated by the Y2 receptor; Eur. J. Neuroscience 22, 1417-30.AbstractPDF
Lars Thomas, Holger A. Scheidt, Andrea Bettio, Daniel Huster, Annette G. Beck-Sickinger, Klaus Arnold, Olaf Zschörnig (2005), Membrane interaction of neuropeptide Y detected by EPR and NMR spectroscopy, Biochim. Biophys. Acta 1714, 103-13.AbstractPDF
Michael E. Herbig, Kathrin Weller, Ulrike Krauss, Annette G. Beck-Sickinger, Hans P. Merkle, and Oliver Zerbe (2005) Membrane surface associated helices promote lipid interactions and cellular uptake of human calcitonin-derived cell penetrating peptides, Biophysical J. 89, 4056-66.AbstractPDF
Manja Lang, Richard M. Söll, Franz Dürenberger, Frank Dautzenberg and Annette G. Beck-Sickinger (2004) Structure-activity studies of orexin A and orexin B at the human orexin 1 and orexin 2 receptors led to orexin 2 receptor selective and orexin 1 receptor preferring ligands, J. Med. Chem. 47, 1153-60AbstractPDF
Ulrike Krauss, Martin Müller, Annette G. Beck-Sickinger (2004) In Vitro Gene Delivery by a Novel Human Calcitonin (hCT) derived Carrier Peptide, Bioorg. Med. Chem. Lett. 14, 51-4AbstractPDF
Rahel Tréhin, Ulrike Krauss, R. Muff, Martina Meinecke, Annette G. Beck-Sickinger, Hans P. Merkle (2004) Cellular internalization of human calcitonin derived peptides in MDCK monolayers: A comparative study with tat(47-57) and penetratin(43-58), Pharm. Res. 21, 33-42AbstractPDF
O. Della-Zuana, L. Revereault, A. G. Beck-Sickinger, A. Monge, D.-H. Caignard, J.-L. Fauchere, J.-M. Henlin, V. Audinot, J. A. Boutin, S. Chamorro, M. Feletou, N. Levens (2004) A potent and selective NPY Y5 antagonist reduces food intake but not through blockade of the NPY Y5 receptor, Int. J. Obes. Relat. Metab. Disord. 28, 628-39AbstractPDF
Philip Tovote, Michael Meyer, Annette G. Beck-Sickinger, Stephan von Hörsten, Sven Ove Ögren, Joachim Spiess and Oliver Stiedl (2004) Central NPY receptor-mediated alteration of heart rate dynamics in mice during expression of fear conditioned to an auditory cue, Reg. Peptides 120, 205-14AbstractPDF
P. Bläuenstein, E. G. Garayoa, D. Ruegg, A. Blanc, D. Tourwe, A. G. Beck-Sickinger, P. A. Schubiger (2004) Improving the tumor uptake of (99m)Tc-labelled neuropeptides using stabilized peptide analogues, Cancer Biother. Radiopharm. 19, 181-8AbstractPDF
Kerstin Wagner, Nicole van Mau, Sylvie Boichot, Andrey V. Kajava, Ulrike Krauss, Christian Le Grimmellec, Annette Beck-Sickinger and Frédéric Heitz (2004) Interactions of human calcitonin-fragment 9-32 with phospholipids: a monolayer study, Biophysical J. 87, 386-95AbstractPDF
Michael P. O. Richter, Kai Holland-Nell, and Annette G. Beck-Sickinger (2004) Site specific biotinylation and immobilization of the human aldo/keto reductase AKR1A1, Tetrahedron 60, 7507-13AbstractPDF
M. Tschöp, T. R. Castañeda, H. G. Joost, C. Thöne-Reineke, S. Ortmann, S. Klaus, M. M. Hagen, P. C. Chandler, K. D. Oswald, S. C. Benoit, R. J. Seeley, K. P. Kinzig, T. H. Moran, A. G. Beck-Sickinger, N. Koglin, R. J. Rodgers, J. E. Blundell, Y. Ishii, A. H. Beattie, P. Holch, D. B. Allison, K. Raun, K. Madsen, B. S. Wulff, C. E. Stidsen, M. Birringer, O. J. Kreuzer, M. Schindler, K. Arndt, K. Rudolf, M. Mark, X. Y. Deng, D. C. Withcomb, H. Halem, J. Taylor, J. Dong, R. Datta, M. Culler, S. Craney, D. Flora, D. Smiley, M. L. Heimann (2004) Does gut hormone PYY3-36 decrease food intake in rodents? Nature 430, 165 f.AbstractPDF
Rachel Tréhin, Ulrike Krauss, Annette G. Beck-Sickinger, Hans P. Merkle (2004) Cellular Uptake but low Permeation of Human Calcitonin Derived Cell Penetrating Peptides and Tat(47-57) through Well-Differentiated Epithelial Models, Pharm. Res. 21, 1248-56AbstractPDF
Sylvie Boichot, Ulrike Krauss, Thomas Plénat, Piere-Emmanuel Milhiet, Annette G. Beck-Sickinger, Christian Le Grimellec (2004) Calcitonin derived carrier peptides play a major role in the membrane localisation of a peptide cargo complex, FEBS Lett. 569, 346-50AbstractPDF
Kerstin Wagner, Annette G. Beck-Sickinger, and Daniel Huster (2004) Structural investigations of a human calcitonin-derived carrier peptide in membrane environment by solid-state NMR, Biochemistry 43, 12459-68AbstractPDF
Jürgen Bader, Cornelia M. Deckert, Franka Pluder, Karin Mörl, Norman Koglin, Dirk Koczan, Hans-Jürgen Thiesen, Annette G. Beck-Sickinger (2004) From transcription profile to expression: the signaling repertoire of the SK-N-MC neuroepithelioma cell-line, J. Recept. Signal Transduct. Res. 24, 257-82AbstractPDF
K. Berger, D. Wissmann, C. Ihling, S. Kalkhof, A. Beck-Sickinger, A. Sinz, R. Paschke, D. Führer (2004) Quantitative proteome analysis in benign thyroid nodular disease using the fluorescent ruthenium II tris(bathophenanthroline disulfonate) stain, Mol. Cel.. Endocrinology 227, 21-30AbstractPDF
Dumont Y, Thakur M, Beck-Sickinger A, Fournier A, Quirion R (2004) Characterization of a new neuropeptide Y Y5 agonist radioligand: [125I][cPP(1-7),NPY(19-23),Ala31,Aib32,Gln34]hPP. Neuropeptides 38, 163-74 AbstractPDF
Rachel Tréhin, Hanne M. Nielsen, Hans-Georg Jahnke, Ulrike Krauss, Annette G. Beck-Sickinger, Hans P. Merkle (2004) Metabolic Cleavage of Cell-penetrating Peptides with Epithelial Models: Human Calcitonin (hCT) Derived Peptides, Tat(47-57) and Penetratin(43-58), Biochem. J. 382, 945-56AbstractPDF
Norman Koglin, Chiara Zorn, Raphael Beumer, Christian Bubert, Norbert Sewald, Oliver Reiser, Annette G. Beck-Sickinger (2003) Analogues of Neuropeptide Y Containing b-Aminocyclopropane-carboxylic Acids are the Shortest Linear Peptides Selective for the Y1-Receptor,  Angew. Chem. Int. Ed. 42, 202-5AbstractPDF
Norman Koglin, Chiara Zorn, Raphael Beumer, Christian Bubert, Norbert Sewald, Oliver Reiser, Annette G. Beck-Sickinger (2003) Neuropeptid Y Analoga mit b-Aminocyclopropan-carbonsäure Derivaten sind die kürzesten linearen und selektiven Peptide am Y1 Rezeptor,  Angew. Chem. 115, 212-5AbstractPDF
Michaela C. Dinger, Jürgen E. Bader, Andreas D. Kóbor, Antje K. Kretzschmar and Annette G. Beck-Sickinger (2003) Homodimerization of NPY Receptors Investigated by Fluorescence Resonance Energy Transfer in Living Cells,  J. Biol. Chem. 278, 10562-71AbstractPDF
Danielle Jacques, Sawsan Sader, Claudine Perreault, Alain Fournier, Georges Pelletier, Annette G. Beck-Sickinger, and Magda Descorbeth (2003) Presence of neuropeptide Y and the Y1 receptor in the plasma membrane and nuclear envelope of human endocardial endothelial cells: modulation of intracellular calcium. Can. J. Physiol. Pharmacol. 81, 288-300 AbstractPDF
Regula von Eggelkraut-Gottanka, Annerose Klose, Annette G. Beck-Sickinger, Michael Beyermann (2003) Peptide a-thioester formation using standard Fmoc-chemistry,  Tetrahedron Lett. 44, 3551-4AbstractPDF
Regula von Eggelkraut-Gottanka, Zuzana Machova, Eric Grouzmann, Annette G. Beck-Sickinger (2003) Semisynthesis and characterisation of the first analogues of pro-neuropeptide Y, ChemBioChem. 4, 425-33AbstractPDF
Christian Ihling, Kerstin Berger, Martin M. Höfliger, Dagmer Führer, Annette G. Beck-Sickinger, Andrea Sinz (2003) Nano-high performance liquid chromatography in combination with nano-electrospray ionization fourier transform ion-cyclotron resonance mass spectrometry for proteome analysis, Rapid Comm. Mass Spectrom. 17, 1240-6AbstractPDF
Yvan Dumont, Mira Thakur, Annette Beck-Sickinger, Alain Fournier and Rémi Qurion (2003) Development and characterization of a highly selective neuropeptide Y5 receptor agonist radioligand: [125I][hPP1-17, Ala31, Aib32]-NPY, Br. J. Pharm. 139, 1360-8AbstractPDF
Anne Lecklin, Ingrid Lundell, Suvi Salmela, Pekka T. Männistö, Annette G. Beck-Sickinger and Dan Larhammar (2003) Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs, Br. J. Pharmacol. 139, 1433-40AbstractPDF
Owain W. Howell, Helen E. Scharfman, Herbert Herzog, Lars E. Sundstrom, Annette G. Beck-Sickinger and William P. Gray (2003) Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells, J. Neurochemistry 86, 646-59AbstractPDF
Norman Koglin, Manja Lang, Robert Rennert, Annette G. Beck-Sickinger (2003) Facile and selective nanoscale labeling of peptides in solution using photolabile protecting groups, J. Med. Chem. 46, 4369-72AbstractPDF
Martin M. Höfliger, Gloria López Castejón, Wieland Kiess, Annette G. Beck-Sickinger (2003) Novel Cell Line Selectively Expressing Neuropeptide Y Y2 Receptors, J. Recept. Signal Transduct. Res. 23, 351-60AbstractPDF
Ulrike Krauss, Felix Kratz, Annette G. Beck-Sickinger (2003)  Novel Daunorubicin-Carrier Peptide Conjugates Derived from Human Calcitonin Segments, J. Mol. Recogn. 16, 280-7AbstractPDF
Zuzana Machova, Regula von Eggelkraut-Gottanka, Nicole Wehofsky, Frank Bordusa and Annette G. Beck-Sickinger (2003) Expressed enzymatic ligation: a new approach for the synthesis of chemically modified proteins, Angew. Chem. Int. Ed., 42, 4916-8 (VIP-Paper)AbstractPDF
Zuzana Machova, Regula von Eggelkraut-Gottanka, Nicole Wehofsky, Frank Bordusa and Annette G. Beck-Sickinger (2003) Exprimierte enzymatische Ligation: ein neuer Ansatz für die Synthese chemisch modifizierter Proteine, Angew. Chem. 115, 5065-7AbstractPDF
Ralf David, Zuzana Machova and Annette G. Beck-Sickinger (2003) Semisynthesis and application of carboxyfluorescein-labeled biologically active human interleukin-8, Biol. Chem. 384, 1619-30AbstractPDF
S. Bedoui, S. Miyake, Y. Lin, K. Miyamoto, S. Oki, N. Kawamura, A. Beck-Sickinger, S. von Horsten, T. Yamamura (2003) Neuropeptide Y (NPY) suppresses experimental autoimmune encephalomyelitis: NPY1 receptor-specific inhibition of autoreactive Th1 responses in vivo, J. Immunol. 171, 3451-8AbstractPDF

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Heike A. Wieland, Richard M. Söll, Henri N. Doods, Dirk Stenkamp, Rudolf Hurnaus, B. Lämmle and Annette G. Beck-Sickinger (2002) The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin1 type receptor,  Eur. J. Biochem. 269, 1128-35AbstractPDF
Nina Pronchuk, Annette G. Beck-Sickinger and William F. Colmers (2002) Multiple NPY receptors Inhibit GABA(A) synaptic responses of rat medial parvocellular effector neurons in the hypothalamic paraventricular nucleus,  Endocrinology 143, 535-43AbstractPDF
Daniela Proske, Martin Höfliger, Richard M. Söll, Annette G. Beck-Sickinger, Michael Famulok (2002) First Y2 receptor mimicking anti-NPY-aptamer, J. Biol. Chem. 277, 11416-22AbstractPDF
Michaela Dinger and Annette G- Beck-Sickinger (2002) The first reporter gene assay on living cells,  Mol. Biotechn. 21, 9-18AbstractPDF
Bouchaib El Bahh, Jeffrey Q. Cao, Annette G. Beck-Sickinger, William F. Colmers (2002) Blockade of Neuropeptide Y2 Receptors and Suppression of NPY's Antiepileptic Actions in the Rat Hippocampal Slice by BIIE 0246,  Br. J. Pharmacol. 136, 502-9AbstractPDF
Reto Bader, Gabriela Ryth, Mirjam Lerch, Annette Beck-Sickinger, Oliver Zerbe, (2002) The Key Motif to Gain Selectivity at the Neuropeptide Y5-Receptor II: Solution Structure and Dynamics of [Ala31, Pro32]-NPY,  Biochemistry 41, 8031-42AbstractPDF
Chiara Cabrele, Heike A. Wieland, Norman Koglin, Carsten Stidsen, Annette Beck-Sickinger (2002) Ala31-Aib32: Identification of the Key Motif for High Affinity and Selectivity of Neuropeptide Y at the Y5-Receptor,  Biochemistry 41, 8043-9 AbstractPDF
Zuzana Machova, Christiane Mühle, Ulrike Krauss, Rahel Trébin, Annette Koch, Hans-Peter Merkle, Annette G. Beck-Sickinger (2002) Cellular Internalization of Enhanced Green Fluorescent Protein Ligated to Human Calcitonin-based Carrier Peptide,  Chem. Biochem. 3, 672-7AbstractPDF
Mohammed Daghish, Lothar Hennig, Matthias Findeisen, Sabine Giesa, Frank Schumer, Horst Hennig, Annette G. Beck-Sickinger and Peter Welzel (2002) Tetrafunctional photoaffinity labels based on Nakanishi's m-nitro-alkoxy-substituted phenyl-trifluoromethyl diazirine,  Angew. Chem. Int Ed. 41, 2293-7AbstractPDF
Mohammed Daghish, Lothar Hennig, Matthias Findeisen, Sabine Giesa, Frank Schumer, Horst Hennig, Annette G. Beck-Sickinger and Peter Welzel (2002) Tetrafunktionelle Reagentien für die Affinitätschromatographie, die sich von Nakanishis m-Nitroalkoxy-substituiertem Phenyltrifluormethyldiazirin ableiten, Angew. Chem. 114, 2404-8 AbstractPDF
Roberto La Bella, Elisa Garcia-Garayoa, Michael Langer, Peter Bläuenstein, Annette G. Beck-Sickinger & Pius A. Schubiger (2002) In vitro and in vivo evaluation of a 99mTC(I)-tricarbonyl labeled high affinity bombesin analogue for imaging of gastrin releasing peptide receptor-positive tumors,  Nucl. Med. Biol. 29, 553-60AbstractPDF
Daili Jacqueline Aguilar Netz, Regula Pohl, Annette G. Beck-Sickinger, Antonio J. Pierik, Thorsten Selmer, Maria do Carmo de Freire Bastos and Hans-Georg Sahl (2002) Biochemical characterization and genetic analysis of aureocin A53, a new, atypical bacteriocin from Staphylococcus aureus,  J. Mol. Biol. 319, 745-56AbstractPDF
Andrea Bettio, Michaela C. Dinger and Annette G. Beck-Sickinger (2002) The Neuropeptide Y Monomer in Solution is Not Folded in the PP-Fold,  Protein Sci. 11, 1834-44AbstractPDF
Mirjana Dimitrijevic, Stanislava Stanojevic, Vesna Vujic, Vesna Kovacevic-Jovanovic, Annette G. Beck-Sickinger, Hans-Ulrich Demuth, Stephan von Hörsten (2002) Effect of neuropeptide Y (NPY) on inflammatory paw edema in the rat: involvement of peripheral NPY Y1 and Y5 receptors and interaction with dipeptidyl-peptidase IV (CD26),  J. Neuroimmunol.  129, 35-42AbstractPDF
Sammy Bedoui, Sandra Lechner, Thomas Gebhardt, Heike Nave, Annette G. Beck-Sickinger, Rainer H. Straub, Reinhard Pabst, Stephan von Hörsten (2002) NPY modulates epinephrine-induced leukocytosis via Y-1 and Y-5 receptor activation in vivo: sympathetic co-transmission during leukocyte mobilization,  J. Neuroimmunol.  132, 25-33AbstractPDF
Andrea Bettio, Volker Gutewort, Andreas Pöppl, Michaela C. Dinger, Olaf Zschörnig, Klaus Arnold, Claudio Toniolo, Annette G. Beck-Sickinger (2002) Backbone Dynamics Studies on Spin-Labelled Neuropeptide Y Analogues by Electron Paramagnetic Resonance Spectroscopy,  J. Pept. Sci. 8, 671-82AbstractPDF
Csaba Fekete, Sumit Sarkar, William M. Rand, John W. Harney, Charles H. Emerson, Antonio C. Bianco, Annette G. Beck-Sickinger, Ronald M. Lechan (2002) Neuropeptide Y1 and Y5 receptors mediate the effects of neuropeptide Y on the hypothalamic-pituitary-thyroid axis,  Endocrinology 143, 4513-9AbstractPDF
Reto Bader, Andrea Bettio, Gerd Folkers, Annette G. Beck-Sickinger, and Oliver Zerbe (2001) Structure and Dynamics of Micelle-bound Neuropeptide Y: Comparison with unligated NPY and Implications for Receptor Selection,  J. Mol. Biol. 305, 307-29 AbstractPDF
Katharina Hoffmann, Richard M. Söll, Annette G. Beck-Sickinger, Manfred Jung (2001) Fluorescence-labeled octapeptides as substrates for histone deacetylase,  Bioconj. Chem. 12, 51-5AbstractPDF
Magnus M. Berglund, Ingrid Lundell, Hendrik Eriksson, Richard Söll, Annette G. Beck-Sickinger, Dan Larhammar (2001) Studies of the Human, Rat, and Guinea Pig Y4 Receptors Using Neuropeptide Y Analogues and Two Distinct Radioligands,  Peptides 22, 351-6AbstractPDF
Chiara Cabrele, Heike A. Wieland, Michael Langer, Carsten Stidsen and Annette G. Beck-Sickinger (2001) Y-Receptor Affinity Modulation by the Design of Pancreatic Polypeptide/Neuropeptide Y Chimera Led to Y5-Receptor Ligands with Picomolar Affinity,  Peptides 22, 365-78AbstractPDF
Christophe Eckard, Chiara Cabrele, Heike Wieland, Annette G. Beck-Sickinger (2001) Molecular characterisation of NPY receptors using synthetic peptides and anti-receptor antibodies,  Molecules 6, 448-67PDF
Michael Langer, Felix Kratz, Barbara Rothen-Rutishauser, Heidi Wunderli-Allenspach and Annette G. Beck-Sickinger (2001) Novel peptide conjugates for tumor specific chemotherapy,  J. Med. Chem. 44, 1341-8AbstractPDF
Richard M. Söll, Michaela Dinger, Ingrid Lundell; Dan Larhammar and Annette G. Beck-Sickinger (2001) The first analogue of neuropeptide Y with preference for the Y1 receptor,  Eur. J. Biochem. 268, 2828-37AbstractPDF
Didier-David Malis, Beate Rist, Keyvan Nicoucar, Annette G. Beck-Sickinger, Denis Morel, Jean-Silvain Lacroix (2001) Modulatory effect of 2 novel CGRP1-receptor antagonists on nasal vasodilatory response to exogenous CGRP, histamine, bradykinin and capsaicin in anaesthetised pigs,  Reg. Peptides 101, 101-8 AbstractPDF
N. Frei, J. Weissenberger, M. Höfliger, A. G. Beck-Sickinger, J. Weis and H. Imboden (2001) Immunocytochemical localization of angiotensin II receptor subtypes and angiotensin II with monoclonal antibodies in the rat adrenal gland,  Reg. Peptides 101, 149-55AbstractPDF
Caspar Demuth, Oliver Zerbe, Didier Rognan, Richard Söll, Annette G. Beck-Sickinger, Gerd Folkers & Ursula Spichiger (2001) A rationally designed oligopeptide shows significant conformational changes upon binding to sulfate ions,  Biosens. Bioelectron. 16, 783-9AbstractPDF
Michael Langer, Roberto La Bella, Pius A. Schubiger & Annette G. Beck-Sickinger (2001) 99mTc-labelled neuropeptide Y analogues as potential tumor imaging agents,  Bioconj. Chem. 12, 1028-34AbstractPDF
Melisa W.Y. Ho, Annette G. Beck-Sickinger, William F. Colmers (2000) Neuropeptide Y5 Receptor-Mediated Inhibition of Synaptic Excitation In Proximal Subiculum Declines With Age and Does Not Affect Epileptiform Bursting in Rat Hippocampal Slice,  J. Neurophysiol. 83, 723-34AbstractPDF
Karen McCrea, Todd Wisialowski, Chiara Cabrele, Bret Church, Annette G. Beck-Sickinger, Edward Kraegen, Herbert Herzog (2000) 2-36[K4,RYYSA19-23]PP a novel Y5-receptor preferring ligand with strong stimulatory effect on food intake,  Reg. Peptides 87, 47-58 AbstractPDF
Chiara Cabrele, Annette G. Beck-Sickinger (2000) Molecular characterisation of the ligand receptor interactions of the NPY/PP peptide family,  J. Peptide Sci. 6, 97-122AbstractPDF
Richard Söll, Annette G. Beck-Sickinger (2000) On the synthesis of orexin A: A novel protocol to obtain peptides with two intramolecular disulfide bonds,  J. Peptide Sci. 6, 387-97AbstractPDF
Marlies Fabry, Michael Langer, Barbara Rothen-Rutishauser, Heidi Wunderli-Allenspach, Hartwig Höcker, Annette G. Beck-Sickinger (2000) Monitoring of the Internalization of Neuropeptide Y on Neuroblastoma Cell Line SK-N-MC,  Eur. J. Biochem. 267, 5631-7AbstractPDF
Magnus M. Berglund, Ingrid Lundell, Chiara Cabrele, Claudine Serradeil-Le Gal, Annette G. Beck-Sickinger and Dan Larhammar (2000) Structure-activity studies of three neuropeptide Y receptor subtypes from zebrafish,  Biochem. Pharmacol. 60, 1815-22AbstractPDF
Chiara Cabrele, Michael Langer, Reto Bader, Heike Wieland, Henry N. Doods, Oliver Zerbe, Annette G. Beck-Sickinger (2000) The first selective agonist at the neuropeptide Y Y5-receptor increases food intake in rats,  J. Biol. Chem. 275, 46, 36043-8AbstractPDF
Marlies Fabry, Chiara Cabrele, Hartwig Höcker, Annette G. Beck-Sickinger (2000) Differently labelled ligands for rapid investigation of receptor expression on a new human glioblastoma cell line,  Peptides 21, 1885-93AbstractPDF
S. Gonser, N. E. A. Crompton, P. J. A. Weber, A. G. Beck-Sickinger, G. Folkers (1999) TP5 triggers signal transduction involving mitogen activated protein kinases in monocytes,  J. Recept. Signal Transduct. Res.  19, 155-66AbstractPDF
Christophe P. Eckard, Annette G. Beck-Sickinger, Heike A. Wieland (1999) Comparison of antibodies directed against receptor segments of NPY-receptors,  J. Recept. Signal Transduct. Res. 19, 379-94AbstractPDF
Beate Rist, Silvain Lacroix, Michael Enzeroth, Henry N. Doods, Annette Beck-Sickinger (1999) CGRP27-37 analogues with high affinity to the CGRP1 receptor show antagonistic properties in a rat blood flow assay,  Regul. Pept. 79, 153-8AbstractPDF
Nikolaus Ingenhoven, Christophe Eckard, Donald Gehlert, Annette G. Beck-Sickinger (1999) Molecular characterisation of the human Y2 receptor,  Biochemistry 38, 6897-902AbstractPDF
Chiara Cabrele, Michael Langer & Annette G. Beck-Sickinger (1999) Amino acid side chain attachment approach and its application to the synthesis of tyrosine-containing cyclic peptides,  J. Org. Chem. 64, 4353-61AbstractPDF
P. Sharma, A. K. Arvidsson, A. Wraith, A. G. Beck-Sickinger, A.-C. Jönsson-Rylander, D. Larhammar (1999) Characterization of the cloned atlantic cod neuropeptide Y-Yb receptor: peptide-binding requirements distinct from known mammalian receptors,  Gen. Comp. Endocrinol. 115, 422-8AbstractPDF
Peter J. A. Weber, Christophe P. Eckard, Susanne Gonser, Heike Otto, Gerd Folkers, Annette G. Beck-Sickinger (1999) On the role of thymopoietins in cell proliferation. Immunochemical evidence for new members of the human thymopoietin family,  Biol. Chem. 380, 653-60AbstractPDF

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Beate Rist, Michael Enzeroth & Annette G. Beck-Sickinger (1998) From micromolar to nanomolar affinity: A systematic approach to identify the binding site of CGRP at the hCGRP1 receptor,  J. Med. Chem. 41, 117-23AbstractPDF
Peter J. A. Weber, Jürgen E. Bader, Gerd Folkers and Annette G. Beck-Sickinger (1998) A fast and inexpensive method for N-terminal fluorescein-labeling of peptides,  Bioorg. Med. Chem. Lett. 8, 597-600AbstractPDF
Virginia Pickel, Annette G. Beck-Sickinger, June Chan & Heike A. Wieland (1998) Y1 Receptors in the Nucleus Accumbens: Ultrastructural Localization and Association with Neuropeptide Y,  J. Neurosci. Res. 52, 54-68AbstractPDF
Heike A Wieland, Christophe Eckard, Henry N. Doods, Annette G. Beck-Sickinger (1998) Probing of the Neuropeptide Y -Y1 receptor interaction with anti-receptor antibodies,  Eur. J. Biochem. 255, 595-603AbstractPDF
Maria Christiane Schmidt, Barbara Rothen-Rutishauser, Beate Rist, Annette G. Beck-Sickinger, Heidi Wunderli-Allenspach, Werner Rubas, Wolfgang Sadée, Hans Peter Merkle (1998) Translocation of human calcitonin in respiratory nasal epithelium is associated with self-assembly in lipid membrane,  Biochemistry 37, 16582-90AbstractPDF
Helen Cox, Iain R. Tough, Nikolaus Ingenhoven and Annette G. Beck-Sickinger (1998) Structure-activity relationships with neuropeptide Y analogues: a comparison of human Y1-, Y2- and rat Y2-like systems,  Regul. Pept. 75-76, 3-8AbstractPDF
Parul Sharma, Sara K. Holmberg, Henrik Eriksson, Annette G. Beck-Sickinger, Lars Grundemar, and Dan Larhammar (1998) Cloning and functional expression of the guinea pig neuropeptide Y Y2 receptor,  Regul. Pept. 75-76, 23-28AbstractPDF
Henrik Behrends, Gerd Folkers, Annette G. Beck-Sickinger (1997) A new approach to secondary structure evaluation: Secondary structure prediction of porcine adenylate kinase and yeast guanylate kinase by circular dichroism spectroscopy of overlapping synthetic peptide segments,  Biopolymers 41, 213-31AbstractPDF
Nikolaus Ingenhoven and Annette G. Beck-Sickinger (1997) Fluorescence labelled analogues of neuropeptide Y for the characterisation of cells expressing NPY receptor subtypes,  J. Recept. Signal Transduct. Res. 17, 407-18AbstractPDF
Peter A. J. Weber & Annette G. Beck-Sickinger (1997) Comparison of the photochemical behavior of four different photoactivatable probes,  J. Peptide Res.  49, 375-83AbstractPDF
Herbert Herzog, Karen Darby, Helen Ball, Yvonne Hort, Annette G. Beck-Sickinger, & John Shine (1997) The human neuropeptide Y receptor subtypes Y1 and Y5 form an overlapping gene cluster on chromosome 4q31-32,  Genomics 41, 315-9AbstractPDF
Beate Rist, Nikolaus Ingenhoven, Leonardo Scapozza, Gerd Schnorrenberg, Wolfram Gaida, Heike A. Wieland & Annette G. Beck-Sickinger (1997) The bioactive conformation of neuropeptide Y at the human Y2 receptor,  Eur. J. Biochem. 247, 1019-28AbstractPDF
Stephan Uebel, Titia Plantinga, Peter J. A. Weber, Annette G. Beck-Sickinger and Robert Tampé (1997) Peptide binding and photo-crosslinking to detergent solubilized and to lipid-reconstituted transporter associated with antigen processing (TAP),  FEBS Lett. 416, 359-63AbstractPDF
Noureddine Brakch, Beate Rist, Annette G Beck-Sickinger, Jaqueline Goenaga, Riccardo Wittek, Erich Bürger, Hans R Brunner & Eric Grouzmann (1997) Role of prohormone convertases in pro-neuropeptide Y processing: coexpression and in vitro kinetic investigations,  Biochemistry 36, 16309-20AbstractPDF
L. J. Mark Cross, Annette G. Beck-Sickinger, Michael Bienert, Wolfram Gaida, Günther Jung, Eberhard Krause, Madeleine Ennis (1996) Structure activity studies of mast cell activation and hypotension induced by neuropeptide Y (NPY), centrally truncated and C-terminal NPY analogues,  Br. J. Pharm. 117, 325-32AbstractPDF
Martine Sautel, Klaus Rudolf, Helmut Wittneben, Herbert Herzog, Raquel Martinez, Miguel Munoz, Wolfgang Eberlein, Wolfhard Engel, Philippe Walker & Annette G. Beck-Sickinger (1996) Neuropeptide Y and the non peptide antagonist BIBP 3226 share a large overlapping binding site at the human Y1 receptor,  Mol. Pharmacol. 50, 285-92AbstractPDF
Susanne Hoffmann, Beate Rist, Klaus Rudolf, Heike A. Wieland, Georgi Videnov, Klaus-Dieter Willim, Wolfgang Eberlein, Wolfhard Engel, Günther Jung & Annette G. Beck-Sickinger (1996) Structure-affinity studies of C-terminally modified analogs of neuropeptide Y led to a novel class of peptidic Y1 receptor antagonists,  Regul. Pept. 65, 61-70AbstractPDF
Beate Rist, Oliver Zerbe, Nikolaus Ingenhoven, Leonardo Scapozza, Chris Peers, Peter F. T. Vaughan, Ruth L. Mc Donald, Heike Wieland and Annette G. Beck-Sickinger (1996) Modified, cyclic dodeca-peptide analog of neuropeptide Y is the smallest full agonist at the human Y2 receptor,  FEBS Lett. 394, 169-73AbstractPDF
Henrik Behrends, Annette G. Beck-Sickinger, Gerd Folkers (1996) Evaluation of the secondary structure of vaccinia-virus thymidine kinase by circular dichroism spectroscopy of overlapping synthetic peptides,  Eur. J. Biochem. 241, 126-32AbstractPDF
Annette G. Beck-Sickinger, Heike A. Wieland & Josef Brunner (1995) Synthesis, affinity and photocrosslinking of photoactive analogues of neuropeptide Y,  J. Recept. Signal Transduct. Res. 15, 473-85AbstractPDF
Annette G. Beck-Sickinger, Matthias Kiess, Petra Kern & Gerd Folkers (1995) Secondary structure prediction of adenylate kinase by circular dichroism spectroscopy of synthetic peptides,  Pharm. Acta Helv.  70, 33-41AbstractPDF
Jörg W. Metzger, Annette G. Beck-Sickinger, Manuel Loleit, Marianne Eckert, Wolfgang G. Bessler & Günther Jung (1995) Synthetic S-[2,3-dihydroxypropyl]-cysteinyl peptides derived from the N-terminus of the cytochrom-subunit of the photoreaction centre of Rhodopseudomonas viridis enhance murine splenocyte proliferation,  J. Pept. Sci. 1, 184-90AbstractPDF
Insa Flechsler, Annette G. Beck-Sickinger, Holger Stephan, Robert Sheppard & Günther Jung (1995) Anchor-linked intermediates in peptide amide synthesis are caused by dimeric anchors on solid supports,  J. Pept. Sci. 1, 191-200AbstractPDF
R. L. McDonald, A. G. Beck-Sickinger, B. Rist, P. F. T. Vaughan and C. Peers (1995) Low potency inhibition of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by [Ala31] NPY, an L-alanine substituted analogue of neuropeptide Y,  Neurosci. Lett. 190, 179-82AbstractPDF
Martine Sautel, Raquel Martinez, Miquel Munoz, Manual C. Peitsch, Annette G. Beck-Sickinger & Philippe Walker (1995) Role of a hydrophobic pocket of the human Y1 neuropeptide Y receptor in ligand binding,  Mol. Cell. Endocrinol. 112, 215-22AbstractPDF
R. L. McDonald, P. F. T. Vaughan, A. G. Beck-Sickinger & C. Peers (1995) Inhibition of Ca2+ channel currents in human neuroblastoma (SH-SY5Y) cells by neuropeptide Y and a novel cyclic neuropeptide Y analogue,  Neuropharmacology 34, 1507-14AbstractPDF
Beate Rist, Heike A. Wieland, Klaus-Dieter Willim & Annette G. Beck-Sickinger (1995) A rational approach for the development of reduced-size analogues of neuropeptide Y with high affinity to the Y1 receptor,  J. Pept. Sci. 1, 341-8AbstractPDF
Annette G. Beck-Sickinger, Eike Hoffmann, Klaus Paulini, Hans-Ulrich Reissig, Klaus-Dieter Willim, Günther Jung (1994) High affinity analogues of neuropeptide Y containing conformationally restricted non-proteinogenic amino acids,  Biochem. Soc. Trans. 22, 145-9AbstractPDF
L. J. Mark Cross, Annette G. Beck-Sickinger, Michael Beyermann, Eberhard Krause, Michael Bienert, Madeleine Ennis (1994) Neuropeptide Y-induced mast cell activation,  Biochem. Soc. Trans. 22, 75 AbstractPDF
Annette G. Beck-Sickinger, Heinz Rothering, Karl-Heinz Wiesmüller, Friedrich Dorner & Günther Jung (1994) Mapping of antigenic and immunogenic sites of Haemophilus influenzae outer membrane protein P6 using synthetic lipopeptides,  Biol. Chem. Hoppe Seyler 375, 173-82 AbstractPDF
Dietmar Steverding, York-Dieter Stierhof, Maliha Chaudhri, Marjolijn Ligtenberg, Dietmar Schell, Annette G. Beck-Sickinger & Peter Overath (1994) ESAG 6 and 7 products of Trypanosoma brucei form a transferrin binding protein complex,  Eur. J. Cell Biol. 64, 78-87AbstractPDF
D. Evéquoz, E. Grouzmann, A. G. Beck-Sickinger, H.-R. Brunner & B. Waeber (1994) Differential vascular effects of neuropeptide Y (NPY) selective receptor agonists,  Experientia 50, 936-8AbstractPDF
Annette G. Beck-Sickinger, Heike A. Wieland, Helmut Wittneben, Klaus-Dieter Willim, Klaus Rudolf & Günther Jung (1994) Complete L-alanine scan of neuropeptide Y reveals ligands binding to Y1 and Y2 receptors with distinguished conformations,  Eur. J. Biochem. 225, 947-58AbstractPDF
Klaus Rudolf, Wolfgang Eberlein, Wolfhard Engel, Heike A. Wieland, Klaus D. Willim, Michael Enzeroth, Wolfgang Wienen, Annette G. Beck-Sickinger & Henri N. Doods (1994) The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist: BIBP 3226,  Eur. J. Pharmacol. 271, R11-3AbstractPDF
Annette G. Beck-Sickinger, Herbert Köppen, Eike Hoffmann, Wolfram Gaida, Günther Jung (1993) Cyclopeptide analogs for characterization of the neuropeptide Y Y2-receptor,  J. Recept. Res. 13, 215-28 AbstractPDF
Stefan Stevanovic, Karl-Heinz Wiesmüller, Jörg Metzger, Annette G. Beck-Sickinger, Günther Jung (1993) Natural and synthetic peptide pools: Characterization by sequencing and electrospray mass spectrometry,  Bioorg. Med. Chem. Letts. 3, 431-6AbstractPDF
Annette G. Beck-Sickinger, Eike Hoffmann, Wolfram Gaida, Eric Grouzmann, Hansjörg Dürr, Günther Jung (1993) Novel Y2-selective reduced-size agonists of neuropeptide Y,  Bioorg. Med. Chem. Letts. 3, 937-42AbstractPDF
Elisabeth G. Pollerberg & Annette G. Beck-Sickinger (1993) A functional role for the middle extracellular region of the neutral cell adhesion molecule (NCAM) in axonal fasciculation and orientation,  Dev. Biol. 156, 324-40AbstractPDF
Hans-Joachim Gaus, Annette G. Beck-Sickinger, Ernst Bayer (1993) Optimization of capillary electrophoresis of mixtures of basic peptides and comparison with HPLC,  Anal. Chem. 65, 1399-1405AbstractPDF
E. Weber, H. P. Lehmann, A. G. Beck-Sickinger, E. J. Wawrzynczak, R. Waibel, G. Folkers & R. A. Stahel (1993) Antibodies to the protein core of the small cell lung cancer workshop antigen cluster-w4 and to the leukocyte workshop antigen CD24 recognize the same short protein sequence leucyl-alanyl-proline,  Clin. Exp. Immunol. 93, 279-85AbstractPDF
Annette G. Beck-Sickinger & Günther Jung (1993) Synthesis and conformational analysis by circular dichroism of lantibiotic leader, pre- and propeptides,  Liebigs Ann. Chem. 1993, 1125-31PDF
Dietmar Ochs, Cortina Kaletta, Karl-Dieter Entian, Annette G. Beck-Sickinger, Karl Poralla (1992) Cloning, expression and sequencing of squalene-hopene cyclase, a key enzyme in triterpenoid metabolism, J. Bacteriol. 174, 298-302 AbstractPDF
Harald Burkhardt, Tan Yan, Barbara Bröker, Annette Beck-Sickinger, Rikard Holmdahl, Klaus Von der Mark & Frank Emmrich (1992) Peptide protection provides a novel way of inhibiting autoreactive T-cells,  Eur. J. Immunol. 22, 1063-7AbstractPDF
Annette G. Beck-Sickinger, Eric Grouzmann, Eike Hoffmann, Wolfram Gaida, Erwin G. Van Meier, Bernard Waeber, Günther Jung (1992) A novel cyclic analog of neuropeptide Y specific for the Y2 receptor,  Eur. J. Biochem. 206, 957-64AbstractPDF
Yoshiaki Sudo, Dario Valenzuela, Annette G. Beck-Sickinger, Mark C. Fishman, Stephen M. Strittmatter (1992) Palmitoylation alters protein activity: Blockade of Go stimulation by GAP-43,  EMBO J.  11, 2095-102AbstractPDF
S. Becker, E. Prusak-Sochaczwski, G. Zamponi, A. G. Beck-Sickinger, R. D. Gordon & R. J. French (1992) Action of derivatives of m-conotoxin GIIIA (m-CTX) on sodium channels. Single amino acid substitutions in the toxin separately affect association and dissociation rates,  Biochemistry 31, 8229-38AbstractPDF
Annette G. Beck-Sickinger, Hansjörg Dürr, Wolfram Gaida, Günther Jung (1992) Characterization of the binding site of neuropeptide Y to the rabbit kidney receptor using multiple peptide synthesis,  Biochem. Soc. Trans. 20, 847-50AbstractPDF
Martin C. Michel, Wolfram Gaida, Annette G. Beck-Sickinger, Heike A. Wieland, Henry Doods, Hansjörg Dürr, Günther Jung, Gerd Schnorrenberg (1992) Further characterization of Neuropeptide Y receptor subtypes using centrally truncated analogs of neuropeptide Y: Evidence for subtype differentiating effects on affinity and intrinsic efficacy,  Mol. Pharmacology 42, 642-48AbstractPDF
Günther Jung, Annette G. Beck-Sickinger, Hansjörg Dürr, Wolfram Gaida & Gerd Schnorrenberg (1991) a-Helical, small molecular size analogues of Neuropeptide Y: Structure-activity-relationships, Biopolymers 31, 613-9AbstractPDF
Annette G. Beck-Sickinger, Gerd Schnorrenberg, Jörg Metzger & Günther Jung (1991) Sulfonation of arginine residues as side reaction in peptide synthesis, Int. J. Pept. Protein Res. 38, 25-31AbstractPDF
Hansjörg Dürr, Annette G. Beck-Sickinger, Gerd Schnorrenberg, Wolfgang Rapp & Günther Jung (1991) Cleavage kinetics and anchor linked intermediates in solid phase peptide amide synthesis, Int. J. Pept. Protein Res. 38, 146-53AbstractPDF
Annette G. Beck-Sickinger, Hansjörg Dürr & Günther Jung (1991) Semiautomated T-bag peptide synthesis using 9-fluorenyl-methoxycarbonyl strategy and benzotriazol-1-yl-tetramethyl-uronium tetrafluoroborate activation, Pept. Res. 4, 88-94AbstractPDF
Eike Hoffmann, Annette G. Beck-Sickinger & Günther Jung (1991) Investigations on different coupling agents for synthesis of a cyclopeptide analogue of neuropeptide Y, Liebigs Ann. Chem. 1991, 585-90PDF
Norbert Zimmermann, Annette G. Beck-Sickinger, Gerd Folkers, Sabine Krickl, Ingrid Müller & Günther Jung (1991) Conformational and epitope mapping of Herpes simplex virus type 1 thymidinekinase using synthetic peptide segments, Eur. J. Biochem. 200, 519-28AbstractPDF
Harald Burkhardt, Tan Yan, Annette Beck-Sickinger, Rikard Holmdahl, Klaus von der Mark & Frank Emmrich (1991) An autoantibody to collagen type II interferes with processing of the antigen thus generating an inhibitory peptide for autoreactive human T-cells, Journal of Cellular Biochemistry O204, Suppl. 15E, 162
Wim van't Hof, Peter C. Driedijk, Marjan van den Berg, Annette G. Beck-Sickinger, Günther Jung, Rob. C. Aalberse (1991) Epitope mapping of the Dermatophagoides pteronyssinus house dust mite major allergen Der p II using overlapping synthesis peptides, Mol. Immunol. 28, 1225-32AbstractPDF
Hans-Peter Weil, Annette G. Beck-Sickinger, Jörg Metzger, Stefan Stevanovic, Günther Jung, Michaela Josten & Hans-Georg Sahl (1990) Biosynthesis of the Lantibiotic Pep5: Isolation and characterisation of a prepeptide containing dehydroamino acids, Eur. J. Biochem. 194, 217-23 AbstractPDF
Annnette G. Beck-Sickinger, Wolfram Gaida, Gerd Schnorrenberg, Rudolph Lang & Günther Jung (1990) Neuropeptide Y: Identification of the binding site, Int. J. Pept. Protein Res. 36, 522-30 AbstractPDF
Annette G. Beck-Sickinger, Günther Jung, Wolfram Gaida, Herbert Köppen, Gerd Schnorrenberg & Rudolph Lang (1990) Structure/activity relationships of C-terminal neuropeptide Y segments and analogues composed of sequence 1-4 linked to 25-36, Eur. J. Biochem. 194, 449-56AbstractPDF
Annette Beck, Günther Jung, Wolfram Gaida, Herbert Köppen, Rudolph Lang & Gerd Schnorrenberg (1989) Highly potent and small Neuropeptide Y agonist obtained by linking NPY 1-4 via spacer to a-helical NPY 25-36, FEBS Lett. 244, 119-22AbstractPDF
Wolfram Gaida, Gerd Schnorrenberg, Herbert Köppen, Annette Beck, Günther Jung, Ursula Mauss & Rudolph Lang (1988) Structure activity studies on NPY and NPY-fragments: Effects on blood pressure, presynaptic action and receptor binding, Neurochem. Int. 13, 114
Lothar Seik, Annette Beck & Claude P. Muller (1988) High-sensitivity isoelectric focusing of biotinylated peptides: A new method, Anal. Biochem. 171, 96-103 AbstractPDF
letzte Änderung: 16.11.2017